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【结 构 式】 
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【分子编号】19480 【品名】(R,R)-Cyclohexane-1,2-diamine dinitrato platinum complex 【CA登记号】n/a |
【 分 子 式 】C6H14N4O6Pt 【 分 子 量 】433.28052 【元素组成】C 16.63% H 3.26% N 12.93% O 22.16% Pt 45.02% |
合成路线1
该中间体在本合成路线中的序号：(I)By reaction of dinitrato (1R,2R-cyclohexanediamine)platinum(II) complex (I) with sodium oxalate (II) in water.
| 【1】 Kidani, Y.; Prous, J.; Castaner, J.; OXALIPLATIN < Rec INN >. Drugs Fut 1989, 14, 6, 529. |
| 【2】 Kidani, Y.; Noji, M.; Tashiro, T.; Antitumor activity of platinum (II) complexes of 1, 2-diaminocyclohexane isomers. Jpn J Cancer Res 1980, 71, 5, 637-43. |
合成路线2
该中间体在本合成路线中的序号：(X)The platinum nitrate derivative (X) was prepared by two related procedures. Halogen-exchange of potassium tetrachloroplatinate (V) with KI produced the tetraiodoplatinate (VI), which was subsequently reacted with trans-1,2-diaminocyclohexane (VII) to give the diamino chelate (VIII). Alternatively, diamine (VII) was reacted with tetrachloroplatinate (V), yielding chelate (IX). Treatment of either iodo compound (VIII) or its analogous chloride (IX) with silver nitrate furnished the dinitrate compound (X). Finally, the diacid formed by basic hydrolysis of anhydride (IV) was in situ complexed with the platinum compound (X) to generate the title platinum complex.
| 【1】 Lin, G.; To, K.K.W.; Wang, X.; Han, X.; Au-Yeung, S.C.F.; Ho, Y.-P.; Potential new antitumor agents from an innovative combination of demethylcantharidin, a modified traditional Chinese medicine, with a platinum moiety. J Med Chem 2001, 44, 13, 2065. |
| 【2】 Ho, Y.P.; Au-Yeung, S.C.F.; Jiang, T.; Han, X.; Wang, X.; Lin, G.; Lu, S. (Chinese University of Hong Kong); Synthesis of platinum complexes and uses thereof. WO 9849174 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 49888 | 4,10-Dioxatricyclo[5.2.1.0(2,6)]decane-3,5-dione | C8H8O4 | 详情 | 详情 | |
| (V) | 51693 | dipotassium tetrachloroplatinate(2-);potassium tetrachloroplatinate(II);potassium tetrachloroplatinate | 10025-99-7 | Cl4K2Pt | 详情 | 详情 |
| (VI) | 51694 | dipotassium tetraiodoplatinate(2-);potassium tetraiodoplatinate(II);Potassium tetraiodoplatinate | 14708-56-6 | I4K2Pt | 详情 | 详情 |
| (VII) | 11130 | (1R,2R)-1,2-cyclohexanediamine; (1R,2R)-2-aminocyclohexylamine; cis-1,2-Diaminocyclohexane | 20439-47-8 | C6H14N2 | 详情 | 详情 |
| (VIII) | 50042 | C6H14I2N2Pt | 详情 | 详情 | ||
| (IX) | 23063 | (R,R)-Cyclohexane-1,2-diamine dichloro platinum complex | C6H14Cl2N2Pt | 详情 | 详情 | |
| (X) | 19480 | (R,R)-Cyclohexane-1,2-diamine dinitrato platinum complex | n/a | C6H14N4O6Pt | 详情 | 详情 |