2,6-dibromo-4-pyridinamine; 2,6-dibromo-4-pyridinylamine -Drug Synthesis Database

【结构式】

【分子编号】19363

【品名】2,6-dibromo-4-pyridinamine; 2,6-dibromo-4-pyridinylamine

【CA登记号】

【分子式】C₅H₄Br₂N₂

【分子量】251.90824

【元素组成】C 23.84% H 1.6% Br 63.44% N 11.12%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Condensation of 4-acetamidobenzenesulfonyl chloride (I) with 4-amino-2,6-dibromopyridine (II) in pyridine at 60 C afforded sulfonamide (III). The acetamido group was then hydrolyzed in refluxing 1 N NaOH to give (IV). Finally, substitution of both bromine atoms for methylamino groups was carried out by heating with liquid MeNH2 at 160 C in an autoclave.

参考文献中间体

合成目标

【1】 Wagner, A.; Heitsch, H.; Nolkne, G.; Wirth, K.; Bernard, P. (Aventis SA); Fluoralkyl- and fluoralkoxy-substd. heterocyclic bradykinin antagonists. EP 0796848; JP 1998007656; US 5859025 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	19362	4-(acetamido)benzenesulfonyl chloride; N-acetylsulfanilyl chloride	121-60-8	C₈H₈ClNO₃S	详情	详情
(II)	19363	2,6-dibromo-4-pyridinamine; 2,6-dibromo-4-pyridinylamine		C₅H₄Br₂N₂	详情	详情
(III)	19364	N-(4-[[(2,6-dibromo-4-pyridinyl)amino]sulfonyl]phenyl)acetamide		C₁₃H₁₁Br₂N₃O₃S	详情	详情
(IV)	19365	4-amino-N-(2,6-dibromo-4-pyridinyl)benzenesulfonamide		C₁₁H₉Br₂N₃O₂S	详情	详情

Extended Information