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【结 构 式】 
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【分子编号】19224 【品名】sodium (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-23-[(1S,2S)-1,2-dihydroxy-2-[4-hydroxy-3-(sulfonatooxy)phenyl]ethyl]-2,11,12,15-tetrahydroxy-6-[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-(palmitoylamino)tetracosahydro-1H-dipyrrolo[2,1-c:2,1-l][1,4,7,10,13,16]hexaazacyclohenicosine 【CA登记号】 |
【 分 子 式 】C51H81N8NaO21S 【 分 子 量 】1197.301228 【元素组成】C 51.16% H 6.82% N 9.36% Na 1.92% O 28.06% S 2.68% |
合成路线1
该中间体在本合成路线中的序号：(F- 901379)The synthesis of FK-463 can be performed as follows: The enzymatic deacylation of FR-901379 with Streptomyces anulatas No. 4811, S. anulatas No. 8703, Streptomyces strain No. 6907 or A. utahensis IFO13244 gives the deacylated lipopeptide FR-179642 (1), which is then reacylated with 1-[4-[5-(4-pentyloxyphenyl)isoxazol-3-yl]benzoyl]benzotriazole 3-oxide (VI) by means of dimethylaminopyridine (DMAP) in DMF. The acylating compound (VI) can be obtained as follows: The cyclization of 4-pentyloxyphenylacetylene (I) with 4-(hydroxyiminomethyl)benzoic acid methyl ester (II) by means of triethylamine in hot THF gives 4-[5-(4-pentyloxyphenyl)isoxazol-3-yl]benzoic acid methyl ester (III), which is hydrolyzed with NaOH in hot THF/water yielding the corresponding free acid (IV). Finally, this compound is condensed with 1-hydroxybenzotriazole (V) by means of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDMCA) in dichloromethane.
| 【1】 Ueda, S.; Ezaki, M.; Tanaka, M.; et al.; Studies on a novel lipopeptide acylase from Streptomyces spp. for production of FR179642, a key intermediate of antifungal lipopeptide drug FK463. 38th Intersci Conf Antimicrob Agents Chemother (Sept 24 1998, San Diego) 1998, Abst F-145. |
| 【2】 Fromtling, R.A.; Castañer, J.; FK-463. Drugs Fut 1998, 23, 12, 1273. |
| 【3】 Ohki, H.; Tomishima, M.; Yamada, A.; Takasugi, H. (Fujisawa Pharmaceutical Co., Ltd.); Cyclic hexapeptides having antibiotic activity. EP 0788511; JP 1998324695; JP 1998507174; US 6107458; WO 9611210 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (F- 901379) | 19224 | sodium (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-23-[(1S,2S)-1,2-dihydroxy-2-[4-hydroxy-3-(sulfonatooxy)phenyl]ethyl]-2,11,12,15-tetrahydroxy-6-[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-(palmitoylamino)tetracosahydro-1H-dipyrrolo[2,1-c:2,1-l][1,4,7,10,13,16]hexaazacyclohenicosine | C51H81N8NaO21S | 详情 | 详情 | |
| (FR-179642) | 19225 | (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-20-(3-amino-1(R)-hydroxy-3-oxopropyl)-23-[1(S),2(S)-dihdyroxy-2-[4-hydroxy-3-(sulfooxy)phenyl]ethyl]-2,11,12,15-tetrahydroxy-6-(1(R)-hydroxyethyl)-16-methylperhydrodipyrrolo[2,1-c:2,1-f][1,4,7,10,13,16]hexaazacyclohenicosine-5,8,14,19,22,25-hexaone | C35H51N8NaO20S | 详情 | 详情 | |
| (I) | 19218 | 4-ethynylphenyl pentyl ether; 1-ethynyl-4-(pentyloxy)benzene | C13H16O | 详情 | 详情 | |
| (II) | 19219 | methyl 4-[(hydroxyimino)methyl]benzoate | C9H9NO3 | 详情 | 详情 | |
| (III) | 19220 | methyl 4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoate | C22H23NO4 | 详情 | 详情 | |
| (IV) | 19221 | 4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoic acid | C21H21NO4 | 详情 | 详情 | |
| (V) | 10184 | 1H-1,2,3-Benzotriazol-1-ol; 1-Hydroxybenzotriazole; 1H-Benzotriazol-1-ol; 1-Benzotriazolol | 2592-95-2 | C6H5N3O | 详情 | 详情 |
| (VI) | 19223 | 3-(4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl)-3H-1,2,3-benzotriazol-1-ium-1-olate | C27H24N4O4 | 详情 | 详情 |