【结 构 式】 |
【分子编号】18987 【品名】(4-bromophenyl)(4'-methyl[1,1'-biphenyl]-4-yl)methanone 【CA登记号】 |
【 分 子 式 】C20H15BrO 【 分 子 量 】351.2425 【元素组成】C 68.39% H 4.3% Br 22.75% O 4.56% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(V)Grignard reagent (II) prepared from 1,4-dibromobenzene (I) was condensed with biphenylaldehyde (III) to afford alcohol (IV), which was oxidized to ketone (V) under Swern conditions with oxalyl chloride and DMSO at low temperature. Then, allylic bromination with N-bromosuccinimide (NBS) in the presence of azobisisobutyronitrile (AIBN) gave (VI). Finally, N-allyl-N-methylamine (VII) was alkylated with bromide (VI) to provide the tertiary amine.
【1】 Aebi, J.; Guerry, P.; Jolidon, S.; Morand, O. (F. Hoffmann-La Roche AG); Use of phenylalkylamines for producing cholesterol lowering agents. EP 0636367; JP 1995053479; US 5637771 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 18983 | 1,4-dibromobenzene | 106-37-6 | C6H4Br2 | 详情 | 详情 |
(II) | 18984 | bromo(4-bromophenyl)magnesium | C6H4Br2Mg | 详情 | 详情 | |
(III) | 18985 | 4'-methyl[1,1'-biphenyl]-4-carbaldehyde | C14H12O | 详情 | 详情 | |
(IV) | 18986 | (4-bromophenyl)(4'-methyl[1,1'-biphenyl]-4-yl)methanol | C20H17BrO | 详情 | 详情 | |
(V) | 18987 | (4-bromophenyl)(4'-methyl[1,1'-biphenyl]-4-yl)methanone | C20H15BrO | 详情 | 详情 | |
(VI) | 18988 | [4'-(bromomethyl)[1,1'-biphenyl]-4-yl](4-bromophenyl)methanone | C20H14Br2O | 详情 | 详情 | |
(VII) | 18989 | N-allyl-N-methylamine; N-methyl-2-propen-1-amine | 627-37-2 | C4H9N | 详情 | 详情 |
Extended Information