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【结 构 式】

【分子编号】18973

【品名】1,1,1,3,3,3-hexafluoro-2-phenyl-2-propanamine hydrochloride

【CA登记号】

【 分 子 式 】C9H8ClF6N

【 分 子 量 】279.6123792

【元素组成】C 38.66% H 2.88% Cl 12.68% F 40.77% N 5.01%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Title compound was prepared by two synthetic ways: 1) Treatment of hexafluorophenylpropanol (I) with KH and then with trifluoromethane- sulfonic anhydride gave triflate (II), which was converted into azide (III) by reaction with NaN3 in trifluoroacetic acid. Reduction of azide (III) with Raney-nickel in isopropanol afforded the corresponding amine, which was isolated as the hydrochloride salt (IV). Acid chloride (VI) was prepared from acid (V) by treatment with SOCl2. Then, condensation of (VI) with amine (IV) in the presence of pyridine provided the target amide.

1 Panzeri, A.; Nesi, M.; Di Salle, E. (Pharmacia & Upjohn AB); Phenylsubstd. 4-azasteroid fluoroderivs.. EP 0793671; JP 1998509188; US 5922728; WO 9710257 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 18970 1,1,1,3,3,3-hexafluoro-2-phenyl-2-propanol 718-64-9 C9H6F6O 详情 详情
(II) 18971 2,2,2-trifluoro-1-phenyl-1-(trifluoromethyl)ethyl trifluoromethanesulfonate C10H5F9O3S 详情 详情
(III) 18972 1-[1-azido-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]benzene; 2,2,2-trifluoro-1-phenyl-1-(trifluoromethyl)ethyl azide C9H5F6N3 详情 详情
(IV) 18973 1,1,1,3,3,3-hexafluoro-2-phenyl-2-propanamine hydrochloride C9H8ClF6N 详情 详情
(V) 13533 (4aS,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid C19H27NO3 详情 详情
(VI) 18975 (4aS,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carbonyl chloride C19H26ClNO2 详情 详情
(VII) 14982 (2R,3R,7S,10R)-7-[(2S,3E,5E,7E,9S,11R)-11-(1,3-dithian-2-yl)-2-methoxy-3,9-dimethyl-3,5,7-dodecatrienyl]-2,3,10-trimethyl-1,4,6-trioxaspiro[4.5]decane; (1S,2E,4E,6E,8S,10R)-10-(1,3-dithian-2-yl)-2,8-dimethyl-1-[[(2R,3R,7S,10R)-2,3,10-trimethyl-1,4,6-trioxaspiro[4.5]dec-7-yl]methyl]-2,4,6-undecatrienyl methyl ether C29H48O4S2 详情 详情
Extended Information