【结 构 式】 |
【分子编号】18689 【品名】4-(3-chloro-4-fluoroanilino)-7-methoxy-6-quinazolinyl acetate 【CA登记号】788136-89-0 |
【 分 子 式 】C17H13ClFN3O3 【 分 子 量 】361.7597432 【元素组成】C 56.44% H 3.62% Cl 9.8% F 5.25% N 11.62% O 13.27% |
合成路线1
该中间体在本合成路线中的序号:(VI)Monodemethylation of 6,7-dimethoxyquinazolin-4(3H)-one (I) in refluxing methanesulfonic acid in the presence of L-methionine provides 6-hydroxy-7-methoxyquinazolin-4(3H)-one (II), which is acetylated with acetic anhydride and pyridine at 100 C to give the acetate (III). Treatment of compound (III) with refluxing SOCl2 and a catalytic amount of DMF yields chloride (IV), which by condensation with 3-chloro-4-fluoroaniline (V) in boiling isopropanol affords the anilinoquinazoline (VI). Hydrolysis of the acetate group of (VI) by treatment with NH4OH in refluxing MeOH gives the 6-hydroxyquinazoline derivative (VII), which finally is alkylated with 3-(4-morpholinyl)-propyl chloride (VIII) or 3-(4-morpholinyl)propyl bromide (IX).
【1】 Gibson, K.H.; Grundy, W.; Barker, A.J.; et al.; Studies leading to the identification of ZD1839 (Iressa(TM)): An orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer. Bioorg Med Chem Lett 2001, 11, 14, 1911. |
【2】 D'Souza, N.; Castañer, J.; Levin, M.; Iressa. Drugs Fut 2002, 27, 4, 339. |
【3】 Gibson, K.H. (AstraZeneca plc); Quinazoline derivs.. EP 0823900; JP 1999504033; US 5770599; WO 9633980 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 18684 | 6,7-dimethoxy-4(3H)-quinazolinone | 13794-72-4 | C10H10N2O3 | 详情 | 详情 |
(II) | 18685 | 6-hydroxy-7-methoxy-4(3H)-quinazolinone | 179688-52-9 | C9H8N2O3 | 详情 | 详情 |
(III) | 18686 | 7-methoxy-4-oxo-3,4-dihydro-6-quinazolinyl acetate | 179688-53-0 | C11H10N2O4 | 详情 | 详情 |
(IV) | 18687 | 4-chloro-7-methoxy-6-quinazolinyl acetate | 230955-75-6 | C11H9ClN2O3 | 详情 | 详情 |
(V) | 18688 | 3-Chloro-4-fluorophenylamine; 3-Chloro-4-fluoroaniline | 367-21-5 | C6H5ClFN | 详情 | 详情 |
(VI) | 18689 | 4-(3-chloro-4-fluoroanilino)-7-methoxy-6-quinazolinyl acetate | 788136-89-0 | C17H13ClFN3O3 | 详情 | 详情 |
(VII) | 18690 | 4-(3-chloro-4-fluoroanilino)-7-methoxy-6-quinazolinol | 184475-71-6 | C15H11ClFN3O2 | 详情 | 详情 |
(VIII) | 18691 | 4-(3-chloropropyl)morpholine;N-(3-Chloropropyl)morpholine | 7357-67-7 | C7H14ClNO | 详情 | 详情 |
(IX) | 52653 | 4-(3-bromopropyl)morpholine | 125422-83-5 | C7H14BrNO | 详情 | 详情 |