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【结 构 式】

【分子编号】18610

【品名】1,8-dibromooctane

【CA登记号】4549-32-0

【 分 子 式 】C8H16Br2

【 分 子 量 】272.02304

【元素组成】C 35.32% H 5.93% Br 58.75%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

Alkylation of potassium phthalimide (I) with an excess of 1,8-dibromooctane (II) in refluxing acetone afforded N-(8-bromooctyl)phthalimide (III). This was condensed with 6-O-demethylgalanthamine (IV) in the presence of Et3N in boiling acetonitrile to give phthalimidooctyl compound (V). Finally, reaction with N-bromosuccinimide in the presence of azobisisobutyronitrile provided the iminium bromide.

1 Mary, A.; Renko, D.Z.; Guillou, C.; Thal, C.; Potent acetylcholinesterase inhibitors: Design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series. Bioorg Med Chem 1998, 6, 10, 1835.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10926 (1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)potassium C8H4KNO2 详情 详情
(II) 18610 1,8-dibromooctane 4549-32-0 C8H16Br2 详情 详情
(III) 18611 2-(8-bromooctyl)-1H-isoindole-1,3(2H)-dione 17702-83-9 C16H20BrNO2 详情 详情
(IV) 18612 (6R,8aS)-3-methoxy-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol C16H19NO3 详情 详情
(V) 18613 2-[8-[(6R,8aS)-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-1H-isoindole-1,3(2H)-dione C32H38N2O5 详情 详情
Extended Information