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【结 构 式】 
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【分子编号】18588 【品名】2-(1-naphthyl)-1-ethanamine hydrochloride 【CA登记号】 |
【 分 子 式 】C12H14ClN 【 分 子 量 】207.7026 【元素组成】C 69.39% H 6.79% Cl 17.07% N 6.74% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Reduction of 1-naphthylacetonitrile (1) by catalytic hydrogenation using Raney Nickel in a NH3 saturated EtOH solution afforded 2-(1-naphthyl)ethylamine, which was then converted to hydrochloride salt (II). Further condensation with cyclobutanecarbonyl chloride (III) in the presence of K2CO3 provided the target amide.
| 【1】 Leclerc, V.; Fourmaintraux, E.; Depreux, P.; Lesieur, D.; Morgan, P.; Howell, H.E.; Renard, P.; Caignard, D.H.; Pfeiffer, B.; Delagrange, P.; Guardiola-Lemaitre, B.; Andrieux, J.; Synthesis and structure-activity relationships of novel naphthalenic and bioisosteric related amidic derivatives as melatonin receptor ligands. Bioorg Med Chem 1998, 6, 10, 1875. |
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