N-(3,5-dimethylphenyl)-2-(4-hydroxyphenyl)acetamide -Drug Synthesis Database

【结构式】

【分子编号】18432

【品名】N-(3,5-dimethylphenyl)-2-(4-hydroxyphenyl)acetamide

【CA登记号】

【分子式】C₁₆H₁₇NO₂

【分子量】255.31652

【元素组成】C 75.27% H 6.71% N 5.49% O 12.53%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Reaction of 4-hydroxyphenylacetic acid (I) with refluxing SOCl2, followed by treatment of the resulting polymeric phenol ester with 3,5-dimethylaniline (II) in refluxing xylene provided amide (III). Condensation of this compound with acetone and chloroform in the presence of powdered NaOH yielded the corresponding isobutyric acid derivative.

参考文献中间体

合成目标

【1】 McIntyre, J.; Castaner, J.; Efaproxiral Sodium. Drugs Fut 2003, 28, 12, 1159.
【2】 Abraham, D.J.; Mehanna, A.; Randad, R.; Mahran, M.; Allosteric hemoglobin modifiers. US 5049695; WO 9112235 .
【3】 Randad, R.S.; et al.; Allosteric modifiers of hemoglobin. 1. Design, synthesis, testing, and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents. J Med Chem 1991, 34, 2, 752.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	18430	2-(4-Hydroxyphenyl)acetic acid; 4-Hydroxyphenylacetic acid	156-38-7	C₈H₈O₃	详情	详情
(II)	18431	3,5-dimethylaniline; 3,5-dimethylphenylamine	108-69-0	C₈H₁₁N	详情	详情
(III)	18432	N-(3,5-dimethylphenyl)-2-(4-hydroxyphenyl)acetamide		C₁₆H₁₇NO₂	详情	详情

Extended Information