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【结 构 式】

【分子编号】18271

【品名】methyl (E)-7-[3-(4-[[(4-cyclohexylbutyl)amino]carbonyl]-1,3-oxazol-2-yl)phenyl]-7-(3-pyridinyl)-6-heptenoate

【CA登记号】

【 分 子 式 】C33H41N3O4

【 分 子 量 】543.70636

【元素组成】C 72.9% H 7.6% N 7.73% O 11.77%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XIV)

Oxazolidine (XIII) was oxidized to oxazole (XIV) with nickel peroxide in the presence of 4 Å molecular sieves, and finally hydrolyzed with 1 M NaOH in THF-MeOH to the title acid.

1 Takeuchi, K.; Kohn, T.J.; Mais, D.E.; True, T.A.; Wyss, V.L.; Jakubowski, J.A.; Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives. Bioorg Med Chem Lett 1998, 8, 15, 1943-1948.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XIII) 18270 methyl (E)-7-[3-((4S)-4-[[(4-cyclohexylbutyl)amino]carbonyl]-4,5-dihydro-1,3-oxazol-2-yl)phenyl]-7-(3-pyridinyl)-6-heptenoate C33H43N3O4 详情 详情
(XIV) 18271 methyl (E)-7-[3-(4-[[(4-cyclohexylbutyl)amino]carbonyl]-1,3-oxazol-2-yl)phenyl]-7-(3-pyridinyl)-6-heptenoate C33H41N3O4 详情 详情
Extended Information