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【结 构 式】 
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【分子编号】18217 【品名】2-(4-chlorobenzoyl)-1-hydrazinecarboximidamide 【CA登记号】 |
【 分 子 式 】C8H9ClN4O 【 分 子 量 】212.63852 【元素组成】C 45.19% H 4.27% Cl 16.67% N 26.35% O 7.52% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The reaction of 4-chlorobenzoylhydrazide (I) with S-methyl isothiourea sulfate in aqueous NaOH gave guanidine (II) which, on heating at 220 C, was converted into aminotriazole (III). Subsequent condensation with methyl isothiocyanate in DMF gave thiocarbonyl triazole (IV). Finally, cyclization with diethoxymethyl acetate at 90 C provided the target triazolotriazine.
| 【1】 Akahoshi, F.; et al.; Synthesis and pharmacological activity of triazolo[1,5-a]triazine derivatives inhibiting eosinophilia. J Med Chem 1998, 41, 16, 2985-2993. |
| 【2】 Naito, Y.; et al.; Synthesis and pharmacological activity of triazole derivatives inhibiting eosinophilia. J Med Chem 1996, 39, 15, 3019-3029. |
| 【3】 Akahoshi, F.; Okada, T.; Takeda, S.; Naito, Y.; Fukaya, C.; Kuwahara, S.; Kajii, M.; Nishimura, H.; Sugiura, M. (Welfide Corporation); Triazole derivs. and pharmaceutical use thereof. EP 0710654; JP 1995082270; JP 1995097321; JP 1995101942; US 5750545; WO 9503286 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 10272 | [[Amino(imino)methyl]sulfanyl]methane | 2986-19-8 | C2H6N2S | 详情 | 详情 | |
| (I) | 18216 | 4-chlorobenzohydrazide; p-chloro-benzoylhydrazine | 536-40-3 | C7H7ClN2O | 详情 | 详情 |
| (II) | 18217 | 2-(4-chlorobenzoyl)-1-hydrazinecarboximidamide | C8H9ClN4O | 详情 | 详情 | |
| (III) | 18218 | 5-(4-chlorophenyl)-1H-1,2,4-triazol-3-ylamine; 5-(4-chlorophenyl)-1H-1,2,4-triazol-3-amine | C8H7ClN4 | 详情 | 详情 | |
| (IV) | 18219 | 5-amino-3-(4-chlorophenyl)-N-methyl-1H-1,2,4-triazole-1-carbothioamide | C10H10ClN5S | 详情 | 详情 | |
| (V) | 17661 | Diethoxymethyl acetate | 14036-06-7 | C7H14O4 | 详情 | 详情 |
Extended Information