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【结 构 式】 
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【分子编号】18176 【品名】1-[[(cyanoimino)(methylsulfanyl)methyl]amino]cyclohexane 【CA登记号】 |
【 分 子 式 】C9H15N3S 【 分 子 量 】197.30432 【元素组成】C 54.79% H 7.66% N 21.3% S 16.25% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Reaction of dimethyl N-cyanodithioiminocarbonate (I) with cyclohexylamine (II) in ethanol afforded isothiourea (III). Then, the title compound was prepared by condensation between an excess of isothiourea (III) and the sodium salt of sulfonamide IV, generated in the presence of NaOH in DMF-dioxane.
| 【1】 Masereel, B.; et al.; Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas. Eur J Med Chem 1997, 32, 5, 453-456. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18174 | [[bis(methylsulfanyl)methylene]amino](nitrilo)methane | 10191-60-3 | C4H6N2S2 | 详情 | 详情 |
| (III) | 18176 | 1-[[(cyanoimino)(methylsulfanyl)methyl]amino]cyclohexane | C9H15N3S | 详情 | 详情 | |
| (IV) | 18177 | 4-(5-Chloro-2-methoxybenzamido ethyl)benzenesulfonamide; 5-Chloro-2-methoxy-n-(2-(4-sulfamoylphenyl)ethyl)benzamide; N-[4-(aminosulfonyl)phenethyl]-5-chloro-2-methoxybenzamide | 16673-34-0 | C16H17ClN2O4S | 详情 | 详情 |
Extended Information