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【结 构 式】 
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【分子编号】18004 【品名】5,6-dichloro-2,1,3-benzoselenadiazole 【CA登记号】 |
【 分 子 式 】C6H2Cl2N2Se 【 分 子 量 】251.96076 【元素组成】C 28.6% H 0.8% Cl 28.14% N 11.12% Se 31.34% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)Phenylenediamine (IV) was protected as the benzoselenadiazole (V) on treatment with selenium dioxide in 1 N HCl. The subsequent nitration with nitric and sulfuric acid provided (VI), which on stirring with a mixture of concentrated HCl and HI gave the nitrodiamine (VII). Cyclization of (VII) with labeled diethyl oxalate (III) in sulfuric acid at 175 C yielded labeled quinoxalinedione.
| 【1】 Thorell, J.O.; et al.; Synthesis of a C-11-labelled nitrated 1,4-dihydroquinoxaline-2,3-dione, the NMDA glycine receptor antagonist ACEA 1021 (Licostinel). J Label Compd Radiopharm 1998, 41, 4, 345-353. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 17571 | Diethyl oxalate; Ethyl 2-ethoxy-2-oxoacetate | 95-92-1 | C6H10O4 | 详情 | 详情 |
| (III) | 45301 | ethyl 2-ethoxy-2-oxoacetate | C6H10O4 | 详情 | 详情 | |
| (IV) | 18003 | 4,5-dichloro-1,2-benzenediamine; 4,5-Dichloro-o-phenylenediamine; 2-amino-4,5-dichlorophenylamine | 5348-42-5 | C6H6Cl2N2 | 详情 | 详情 |
| (V) | 18004 | 5,6-dichloro-2,1,3-benzoselenadiazole | C6H2Cl2N2Se | 详情 | 详情 | |
| (VI) | 18005 | 5,6-dichloro-4-nitro-2,1,3-benzoselenadiazole | C6HCl2N3O2Se | 详情 | 详情 | |
| (VII) | 18006 | 2-amino-4,5-dichloro-3-nitrophenylamine; 4,5-dichloro-3-nitro-1,2-benzenediamine | C6H5Cl2N3O2 | 详情 | 详情 |
Extended Information