4-(chloromethyl)phenyl 2-quinolinylmethyl ether; 2-[[4-(chloromethyl)phenoxy]methyl]quinoline -Drug Synthesis Database

【结构式】

【分子编号】17822

【品名】4-(chloromethyl)phenyl 2-quinolinylmethyl ether; 2-[[4-(chloromethyl)phenoxy]methyl]quinoline

【CA登记号】

【分子式】C₁₇H₁₄ClNO

【分子量】283.757

【元素组成】C 71.96% H 4.97% Cl 12.49% N 4.94% O 5.64%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Reaction of 2-bromo-5-methoxybenzoic acid (I) with hydrazine hydrate gave hydrazinobenzoic acid (II), which was cyclized to indazole (III) on heating with hydrochloric acid. Subsequent alkylation with 2-[4-(chloromethyl)phenoxymethyl]quinoline hydrochloride (IV) in the presence of sodium hydroxide in DMSO provided (V), and treatment of this with HCl in acetone furnished the target dihydrochloride.

参考文献中间体

合成目标

【1】 Schindler, R.; et al.; 1,5-Disubstituted Indazol-3-ols with Anti-Inflammatlory Activity. Arch Pharm 1998, 331, 1, 13-21.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	17819	2-bromo-5-methoxybenzoic acid	22921-68-2	C₈H₇BrO₃	详情	详情
(II)	17820	2-hydrazino-5-methoxybenzoic acid		C₈H₁₀N₂O₃	详情	详情
(III)	17821	5-methoxy-1H-indazol-3-ol		C₈H₈N₂O₂	详情	详情
(IV)	17822	4-(chloromethyl)phenyl 2-quinolinylmethyl ether; 2-[[4-(chloromethyl)phenoxy]methyl]quinoline		C₁₇H₁₄ClNO	详情	详情
(V)	17823	5-methoxy-1-[4-(2-quinolinylmethoxy)benzyl]-1H-indazol-3-ol		C₂₅H₂₁N₃O₃	详情	详情

Extended Information