2-Butyl-4-[N-methyl-N-(3-methyl-2-butenoyl)amino]-1-[2'-[1-(tribenzyl)-1H-tetrazol-5-yl]biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid potassium salt -Drug Synthesis Database

【结构式】

【分子编号】17816

【品名】2-Butyl-4-[N-methyl-N-(3-methyl-2-butenoyl)amino]-1-[2'-[1-(tribenzyl)-1H-tetrazol-5-yl]biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid potassium salt

【CA登记号】

【分子式】C₄₇H₄₄KN₇O₃

【分子量】794.01004

【元素组成】C 71.1% H 5.59% K 4.92% N 12.35% O 6.05%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIV)

The alkaline hydrolysis of the ester group of (XI) yielded acid (XII). Tetrazole ring was then protected by alkylation with trityl chloride to the trityl derivative (XIII), which was then converted to the potassium salt (XIV) with ethanolic KOH. Alkylation of the potassium salt with 1-iodoethyl ethyl carbonate (XV) in acetone provided the acetaldehyde acylal (XVI), and final deprotection of trityl group with ethanolic acetic acid furnished the target compound (1).

参考文献中间体

合成目标

【1】 Okazaki, T.; et al.; Studies on nonpeptide angiotensin II receptor antagonists. IV. Synthesis and biological evaluation of 4-acrylamide-1H-imidazole derivatives. Chem Pharm Bull 1998, 46, 6, 973.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XI)	17813	ethyl 2-butyl-4-[methyl(3-methyl-2-butenoyl)amino]-1-[[2'-(1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylate	C₃₀H₃₅N₇O₃	详情	详情
(XII)	17814	2-butyl-4-[methyl(3-methyl-2-butenoyl)amino]-1-[[2'-(1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid	C₂₈H₃₁N₇O₃	详情	详情
(XIII)	17815	2-butyl-4-[methyl(3-methyl-2-butenoyl)amino]-1-[[2'-(1-trityl-1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid	C₄₇H₄₅N₇O₃	详情	详情
(XIV)	17816	2-Butyl-4-[N-methyl-N-(3-methyl-2-butenoyl)amino]-1-[2'-[1-(tribenzyl)-1H-tetrazol-5-yl]biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid potassium salt	C₄₇H₄₄KN₇O₃	详情	详情
(XV)	17817	ethyl 1-iodoethyl carbonate	C₅H₉IO₃	详情	详情
(XVI)	17818	1-[(ethoxycarbonyl)oxy]ethyl 2-butyl-4-[methyl(3-methyl-2-butenoyl)amino]-1-[[2'-(1-trityl-1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylate	C₅₂H₅₃N₇O₆	详情	详情

Extended Information