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【结 构 式】

【分子编号】17789

【品名】2-Fluoro-4-hydroxybenzonitrile

【CA登记号】82380-18-5

【 分 子 式 】C7H4FNO

【 分 子 量 】137.1133032

【元素组成】C 61.32% H 2.94% F 13.86% N 10.22% O 11.67%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Treatment of 4-hydroxy-3-methoxybenzoic acid (I) with thionyl chloride and then with diisopropyl amine provided amide (II). Alkylation of (II) with 1,4-dibromobutane and potassium carbonate in acetonitrile, followed by treatment with sodium iodide afforded iodobutylether (III). Then, alkylation of 2-fluoro-4-hydroxybenzonitrile (IV) with iodide (III) in the presence of sodium hydride in DMF gave (V), which was condensed with acetone oxime (VI) and potassium tert-butoxide to provide (VII). Finally, cyclization of (VII) in a refluxing hydroalcoholic solution of HCl generated the target benzisoxazole.

1 Suh, H.; et al.; 3-Amino-1,2-benzisoxazoles: A new family of potent inhibitors of LTB4 binding to the human neutrophils. Bioorg Med Chem Lett 1997, 7, 4, 389.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 17786 4-hydroxy-3-methoxybenzoic acid; Vanillic acid 121-34-6 C8H8O4 详情 详情
(II) 17787 4-hydroxy-N,N-diisopropyl-3-methoxybenzamide C14H21NO3 详情 详情
(III) 17788 4-(4-iodobutoxy)-N,N-diisopropyl-3-methoxybenzamide C18H28INO3 详情 详情
(IV) 17789 2-Fluoro-4-hydroxybenzonitrile 82380-18-5 C7H4FNO 详情 详情
(V) 17790 4-[4-(4-cyano-3-fluorophenoxy)butoxy]-N,N-diisopropyl-3-methoxybenzamide C25H31FN2O4 详情 详情
(VI) 17791 acetone oxime; Acetoxime 127-06-0 C3H7NO 详情 详情
(VII) 17792 4-[4-(4-cyano-3-[[(1-methylethylidene)amino]oxy]phenoxy)butoxy]-N,N-diisopropyl-3-methoxybenzamide C28H37N3O5 详情 详情
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