7-[6-O-(6-Deoxy-2,3,4-tetra-O-sulfo-alpha-L-mannopyranosyl)-2,3,4-tetra-O-sulfo-beta-D-glucopyranosyloxy]-5-hydroxy-2-(4-methoxy-3-sulfooxyphenyl)-4H-1-benzopyran-4-one hepta-5-ethyl-2-methylpyridinium salt; 7-[6-O-(6-Deoxy-2,3,4-tetra-O-sulfo-alpha-L-mannopyranosyl)-2,3,4-tetra-O-sulfo-beta-D-glucopyranosyloxy]-5-hydroxy-2-(4-methoxy-3-sulfooxyphenyl)-4H-1-benzopyran-4-one hepta-5-ethyl-2-methylpyridinium salt -Drug Synthesis Database

【结构式】

【分子编号】23462

【品名】7-[6-O-(6-Deoxy-2,3,4-tetra-O-sulfo-alpha-L-mannopyranosyl)-2,3,4-tetra-O-sulfo-beta-D-glucopyranosyloxy]-5-hydroxy-2-(4-methoxy-3-sulfooxyphenyl)-4H-1-benzopyran-4-one hepta-5-ethyl-2-methylpyridinium salt; 7-[6-O-(6-Deoxy-2,3,4-tetra-O-sulfo-alpha-L-mannopyranosyl)-2,3,4-tetra-O-sulfo-beta-D-glucopyranosyloxy]-5-hydroxy-2-(4-methoxy-3-sulfooxyphenyl)-4H-1-benzopyran-4-one hepta-5-ethyl-2-methylpyridinium salt

【CA登记号】

【分子式】C₈₄H₁₀₉N₇O₃₆S₇

【分子量】2017.27704

【元素组成】C 50.01% H 5.45% N 4.86% O 28.55% S 11.13%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

Dosmalfate is obtained in a multistep synthesis: The treatment of anhydrous 5-ethyl-2-methylpyridine (I) with chlorosulfonic acid (II) affords 5-ethyl-2-methylpyridine sulfur trioxide complex (III). Heating 1 mol of diosmin (IV) with 7 mol of (III) gives diosmin heptakis(hydrogensulfate) 5-ethyl-2-methylpyridinium salt (V), which by treatment with aqueous sodium hydroxide yields the diosmin heptakis(hydrogensulfate) sodium salt. Finally, the reaction of the sodium salt in an aqueous medium with an aqueous aluminum hydroxychloride solution yields the diosmin heptakis(hydrogensulfate) aluminum complex.

参考文献中间体

合成目标

【1】 Orjales-Venero, A.; Mosquera-Pestana, R. (FAES); Sulfated diosmin deriv.. EP 0558435; ES 2041216; JP 1994008677; US 5296469 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23458	5-ethyl-2-methylpyridine	104-90-5	C₈H₁₁N	详情	详情
(III)	23460	5-ethyl-2-methylpyridinium		C₈H₁₃NO₃S	详情	详情
(IV)	23461	5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-([[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]methyl)tetrahydro-2H-pyran-2-yl]oxy]-4H-chromen-4-one	520-27-4	C₂₈H₃₂O₁₅	详情	详情
(V)	23462	7-[6-O-(6-Deoxy-2,3,4-tetra-O-sulfo-alpha-L-mannopyranosyl)-2,3,4-tetra-O-sulfo-beta-D-glucopyranosyloxy]-5-hydroxy-2-(4-methoxy-3-sulfooxyphenyl)-4H-1-benzopyran-4-one hepta-5-ethyl-2-methylpyridinium salt; 7-[6-O-(6-Deoxy-2,3,4-tetra-O-sulfo-alpha-L-mannopyranosyl)-2,3,4-tetra-O-sulfo-beta-D-glucopyranosyloxy]-5-hydroxy-2-(4-methoxy-3-sulfooxyphenyl)-4H-1-benzopyran-4-one hepta-5-ethyl-2-methylpyridinium salt		C₈₄H₁₀₉N₇O₃₆S₇	详情	详情

Extended Information