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【结 构 式】 
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【分子编号】17628 【品名】(2R,3R,5S)-2-(6-amino-9H-purin-9-yl)-5-[(trityloxy)methyl]tetrahydro-3-furanol 【CA登记号】 |
【 分 子 式 】C29H27N5O3 【 分 子 量 】493.56528 【元素组成】C 70.57% H 5.51% N 14.19% O 9.72% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The selective tritylation of cordycepin (3'-deoxyadenosine) (I) with trityl chloride in pyridine gives the 5'-O-trityl derivative (II), which is then fluorinated with diethylamido sulfur trifluoride in refluxing dichloromethane and deprotected with hot 80% acetic acid.
| 【1】 Castaner, J.; Graul, A.; Silvestre, J.S.; Lodenosine. Drugs Fut 1998, 23, 11, 1176-1189. |
| 【2】 Baba, M.; De Clercq, E.; Herdewijn, P.; Pauwels, R.; Balzarini, J.; Synthesis and anti-HIV activity of various 2'- and 3'-substituted 2',3'-dideoxyadenosines: A structure-activity analysis. J Med Chem 1987, 30, 11, 2131-7. |
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