3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol hydrochloride -Drug Synthesis Database

【结构式】

【分子编号】17331

【品名】3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol hydrochloride

【CA登记号】

【分子式】C₁₇H₁₉N₃O

【分子量】281.35748

【元素组成】C 72.57% H 6.81% N 14.93% O 5.69%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of N-(3-hydroxyphenyl)-N-(4-methylphenyl)amine (I) with 2-(chloromethyl)-4,5-dihydro-1H-imidazole (II) by heating at 150-60 C without solvent or in o-dichlorobenzene gives phentolamine as hydrochloride salt (III), which is treated with ammonia to obtain the free base, and finally salified with methanesulfonic acid in ethanol.

参考文献中间体

合成目标

【1】 Miescher, K.; Marxer, A.; Urech, E.; 2-Aminoalkyl-imidazoline. Helv Chim Acta 1950, 33, 5, 1386-407.
【2】 Miescher, K.; Marxer, A.; Urech, E. (Novartis Corp.); 2-(N,N-Diphenyl-aminomethyl)imidazoles. US 2503059 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	17329	3-(4-toluidino)phenol	61537-49-3	C₁₃H₁₃NO	详情	详情
(II)	17330	2-(chloromethyl)-4,5-dihydro-1H-imidazole		C₄H₇ClN₂	详情	详情
(III)	17331	3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol hydrochloride		C₁₇H₁₉N₃O	详情	详情

Extended Information