【结 构 式】 |
【分子编号】21503 【品名】5-(1,4-diazepan-1-ylsulfonyl)isoquinoline 【CA登记号】 |
【 分 子 式 】C14H17N3O2S 【 分 子 量 】291.374 【元素组成】C 57.71% H 5.88% N 14.42% O 10.98% S 11.01% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)5-Isoquinolinesulfonic acid (I) is heated at 85 C with SOCl2 and DMF yielding 5-isoquinolinesulfonyl chloride hydrochloride (II). The reaction of (II) with hexahydro-1H-1,4-diazepine affords hexahydro-1-(5-isoquinolinesulfonyl)-1H-1,4-diazepine (III) in CH2Cl2. Finally, the reaction of (III) with HCl gives hexahydro-1-(5-isoquinolinesulfonyl)-1H-1,4-diazepine hydrochloride (IV). (scheme 10964901a)
【1】 Ishida, T.; Asano, T.; HA 1077. Drugs Fut 1989, 14, 12, 1159. |
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