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【结 构 式】 
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【分子编号】19354 【品名】tert-butyl 4-[[(4-amino-5-chloro-2-methoxybenzoyl)amino]methyl]-1-piperidinecarboxylate 【CA登记号】 |
【 分 子 式 】C19H28ClN3O4 【 分 子 量 】397.90184 【元素组成】C 57.35% H 7.09% Cl 8.91% N 10.56% O 16.08% |
合成路线1
该中间体在本合成路线中的序号：(VI)4-(Aminomethyl)piperidine (I) was protected as the benzylideneimine (III) by condensation with benzaldehyde (II). Further acylation of (III) at the secondary amino group by treatment with di-tert--butyl dicarbonate gave, after acid hydrolysis of the imine, the N-Boc-piperidine (IV). The benzoic acid derivative (V) was activated as the mixed anhydride by treatment with ethyl chloroformate and triethylamine, and subsequently condensed with amine (IV) to provide the corresponding amide (VI). Then, the N-tert-butoxycarbonyl group was eliminated with HCl to give the piperidine (VII), which was finally alkylated with halide (VIII) in the presence of K2CO3 in DMF to furnish the title compound.
| 【1】 Baker, S.R.; et al.; Synthesis and pharmacological evaluation of benzamides as selective 5-HT4 receptor agonists. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abs P 270. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 19349 | 4-piperidinylmethylamine; 4-piperidinylmethanamine; 4-(Aminomethyl)piperidine | 7144-05-0 | C6H14N2 | 详情 | 详情 |
| (II) | 10498 | Benzaldehyde;Benzoic aldehyde;Phenylmethanal | 100-52-7 | C7H6O | 详情 | 详情 |
| (III) | 19351 | N-[(E)-benzylidene]-N-(4-piperidinylmethyl)amine; N-[(E)-benzylidene](4-piperidinyl)methanamine | C13H18N2 | 详情 | 详情 | |
| (IV) | 19352 | 4-Aminomethyl-1-N-Boc-piperidine; tert-butyl 4-(aminomethyl)-1-piperidinecarboxylate | 144222-22-0 | C11H22N2O2 | 详情 | 详情 |
| (V) | 12419 | 4-Amino-5-chloro-2-methoxybenzoic acid | 7206-70-4 | C8H8ClNO3 | 详情 | 详情 |
| (VI) | 19354 | tert-butyl 4-[[(4-amino-5-chloro-2-methoxybenzoyl)amino]methyl]-1-piperidinecarboxylate | C19H28ClN3O4 | 详情 | 详情 | |
| (VII) | 19355 | 4-amino-5-chloro-2-methoxy-N-(4-piperidinylmethyl)benzamide | C14H20ClN3O2 | 详情 | 详情 | |
| (VIII) | 19356 | benzyl 4-chlorobutyl sulfone; benzyl(4-chlorobutyl)dioxo-lambda(6)-sulfane | 14633-43-3 | C11H15ClO2S | 详情 | 详情 |