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【结 构 式】

【分子编号】18035

【品名】4'-Amino-5-beta-cyano-7-alpha,4-metheno-3-oxo-17-alpha-pregnane-21,17-carbolactone

【CA登记号】

【 分 子 式 】C24H30N2O3

【 分 子 量 】394.51388

【元素组成】C 73.07% H 7.66% N 7.1% O 12.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IX)

In a related way, canrenone (I) was converted to mexrenone (XI) by an analogous sequence including cyanide addition to give enamine (IX), hydrolysis to diketone (X), and ring opening with NaOMe. The microbiological oxidation of mexrenone (XI) yielded either the 9-a (XII) or the 11-b (XIII) hydroxylated compounds, which were dehydrated to the olefin (VIII), whose epoxidation, as before, afforded eplerenone.

1 Ng, J.S.; Wang, P.T.; Baez, J.A.; Liu, C.; Anderson, D.K.; Lawson, J.P.; Erb, D.; Wieczorek, J.; Mucciariello, G.; Vanzanella, F.; Kunda, S.A.; Letendre, L.J.; Pozzo, M.J.; Sing, Y.-L.L. (Pharmacia Corp.); Process for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and intermediates useful therein and a general process for the epoxidation of olifinic double bonds. WO 9721720 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
18029 Acetone cyanohydrin; 2-Hydroxy-2-methylpropanenitrile; 2-Hydroxy-2-methylpropionitrile; 2-Hydroxyisobutyronitrile; 2-Methyllactonitrile; alpha-Hydroxyisobutyronitrile 75-86-5 C4H7NO 详情 详情
(I) 18027 3-Oxopregna-4,6-diene-21,17-carbolactone 976-71-6 C22H28O3 详情 详情
(VIII) 18034 7-Alpha-(methoxycarbonyl)-3-oxopregna-4,9(11)-diene-21,17-carbolactone C24H30O5 详情 详情
(IX) 18035 4'-Amino-5-beta-cyano-7-alpha,4-metheno-3-oxo-17-alpha-pregnane-21,17-carbolactone C24H30N2O3 详情 详情
(X) 18036 5-beta-Cyano-4,7-alpha-methano-3,4'-dioxo-17-alpha-pregnane-21,17-carbolactone C24H29NO4 详情 详情
(XI) 18037 7-Alpha-(methoxycarbonyl)-3-oxopregn-4-ene-21,17-carbolactone C24H32O5 详情 详情
(XII) 18038 7-Alpha-(methoxycarbonyl)-9-alpha-hydroxy-3-oxopregn-4-ene-21,17-carbolactone C24H32O6 详情 详情
(XIII) 18039 7-Alpha-(methoxycarbonyl)-11-beta-hydroxy-3-oxopregn-4-ene-21,17-carbolactone C24H32O6 详情 详情
Extended Information