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【结 构 式】 
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【分子编号】18035 【品名】4'-Amino-5-beta-cyano-7-alpha,4-metheno-3-oxo-17-alpha-pregnane-21,17-carbolactone 【CA登记号】 |
【 分 子 式 】C24H30N2O3 【 分 子 量 】394.51388 【元素组成】C 73.07% H 7.66% N 7.1% O 12.17% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IX)In a related way, canrenone (I) was converted to mexrenone (XI) by an analogous sequence including cyanide addition to give enamine (IX), hydrolysis to diketone (X), and ring opening with NaOMe. The microbiological oxidation of mexrenone (XI) yielded either the 9-a (XII) or the 11-b (XIII) hydroxylated compounds, which were dehydrated to the olefin (VIII), whose epoxidation, as before, afforded eplerenone.
| 【1】 Ng, J.S.; Wang, P.T.; Baez, J.A.; Liu, C.; Anderson, D.K.; Lawson, J.P.; Erb, D.; Wieczorek, J.; Mucciariello, G.; Vanzanella, F.; Kunda, S.A.; Letendre, L.J.; Pozzo, M.J.; Sing, Y.-L.L. (Pharmacia Corp.); Process for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and intermediates useful therein and a general process for the epoxidation of olifinic double bonds. WO 9721720 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 18029 | Acetone cyanohydrin; 2-Hydroxy-2-methylpropanenitrile; 2-Hydroxy-2-methylpropionitrile; 2-Hydroxyisobutyronitrile; 2-Methyllactonitrile; alpha-Hydroxyisobutyronitrile | 75-86-5 | C4H7NO | 详情 | 详情 | |
| (I) | 18027 | 3-Oxopregna-4,6-diene-21,17-carbolactone | 976-71-6 | C22H28O3 | 详情 | 详情 |
| (VIII) | 18034 | 7-Alpha-(methoxycarbonyl)-3-oxopregna-4,9(11)-diene-21,17-carbolactone | C24H30O5 | 详情 | 详情 | |
| (IX) | 18035 | 4'-Amino-5-beta-cyano-7-alpha,4-metheno-3-oxo-17-alpha-pregnane-21,17-carbolactone | C24H30N2O3 | 详情 | 详情 | |
| (X) | 18036 | 5-beta-Cyano-4,7-alpha-methano-3,4'-dioxo-17-alpha-pregnane-21,17-carbolactone | C24H29NO4 | 详情 | 详情 | |
| (XI) | 18037 | 7-Alpha-(methoxycarbonyl)-3-oxopregn-4-ene-21,17-carbolactone | C24H32O5 | 详情 | 详情 | |
| (XII) | 18038 | 7-Alpha-(methoxycarbonyl)-9-alpha-hydroxy-3-oxopregn-4-ene-21,17-carbolactone | C24H32O6 | 详情 | 详情 | |
| (XIII) | 18039 | 7-Alpha-(methoxycarbonyl)-11-beta-hydroxy-3-oxopregn-4-ene-21,17-carbolactone | C24H32O6 | 详情 | 详情 |
Extended Information