1-(4-chlorophenyl)-2-[4-(4-fluorobenzyl)piperidino]-1-ethanone -Drug Synthesis Database

【结构式】

【分子编号】16795

【品名】1-(4-chlorophenyl)-2-[4-(4-fluorobenzyl)piperidino]-1-ethanone

【CA登记号】

【分子式】C₂₀H₂₁ClFNO

【分子量】345.8439832

【元素组成】C 69.46% H 6.12% Cl 10.25% F 5.49% N 4.05% O 4.63%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

A new synthesis of eliprodil and the asymmetric synthesis of its two enantiomers have been reported: 1) Racemic eliprodil is obtained by condensation of 4-chlorophenacyl bromide (I) with 4-(4-fluorobenzyl)piperidine (II) by means of K2CO3 in refluxing ethanol to give 1-(4-chlorophenyl)-2-[4-(4-fluorobenzyl)piperidin-1-yl]ethanone (III), which is then reduced with KBH4 in methanol.

参考文献中间体

合成目标

【1】 Di Fabio, R.; Thomas, R.J.; Pietra, C.; Ziviani, L.; The asymmetric synthesis of both enantiomers of eliprodil. Bioorg Med Chem Lett 1995, 5, 6, 551.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	16720	2-bromo-1-(4-chlorophenyl)-1-ethanone; 2-Bromo-4'-chloroacetophenone	536-38-9	C₈H₆BrClO	详情	详情
(II)	16794	4-(4-fluorobenzyl)piperidine	92822-02-1	C₁₂H₁₆FN	详情	详情
(III)	16795	1-(4-chlorophenyl)-2-[4-(4-fluorobenzyl)piperidino]-1-ethanone		C₂₀H₂₁ClFNO	详情	详情

Extended Information