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【结 构 式】 
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【分子编号】16507 【品名】5-methylnicotinic acid 【CA登记号】3222-49-9 |
【 分 子 式 】C7H7NO2 【 分 子 量 】137.13812 【元素组成】C 61.31% H 5.14% N 10.21% O 23.33% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)The key intermediate (VI) is synthesized through the condensation of 5-methylnicotinic acid (VIII) with 4-hydroxypiperidine by means of DCC in DMF to give amide (IX), followed by reduction with POCl3 and NaBH4 to give the amino alcohol (X), which is treated with SOCl2.
| 【1】 Carceller, E.; Jiménez, P.J.; Salas, J. (J. Uriach & Cia., SA); Process for the preparation of 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohepta[1,2-b]pyridine. ES 9602107 . |
| 【2】 García-Rafanell, J.; Rupatadine Fumarate. Drugs Fut 1996, 21, 10, 1032. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 12076 | 4-Piperidinol; 4-Hydroxypiperidine | 5382-16-1 | C5H11NO | 详情 | 详情 | |
| (VI) | 16505 | 4-chloro-1-[(5-methyl-3-pyridinyl)methyl]piperidine | C12H17ClN2 | 详情 | 详情 | |
| (VIII) | 16507 | 5-methylnicotinic acid | 3222-49-9 | C7H7NO2 | 详情 | 详情 |
| (IX) | 16508 | (4-hydroxypiperidino)(5-methyl-3-pyridinyl)methanone | C12H16N2O2 | 详情 | 详情 | |
| (X) | 16509 | 1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinol | C12H18N2O | 详情 | 详情 |
Extended Information