|
【结 构 式】 
|
【分子编号】16498 【品名】Benzocaine; ethyl 4-aminobenzoate 【CA登记号】94-09-7 |
【 分 子 式 】C9H11NO2 【 分 子 量 】165.19188 【元素组成】C 65.44% H 6.71% N 8.48% O 19.37% |
合成路线1
该中间体在本合成路线中的序号：(I)The condensation of ethyl 4-aminobenzoate (I) with 2,5-dimethoxytetrahydrofuran (II) in refluxing acetic acid/toluene gives ethyl 4-(1-pyrrolyl)benzoate (III), which by a Mannich reaction with formaldehyde and dimethylamine, followed by quaternization with methyl iodide in N,N'-dimethylimidazolidininone (DMI) yields the trimethylammonium salt (IV). The reduction of (IV) with borane/pyridine complex in DMI affords ethyl 4-(2-methyl-1-pyrrolyl)benzoate (V), which is treated with chlorosulfonyl isocyanate in heptane/toluene affording ethyl 4-(2-cyano-5-methyl-1-pyrrolyl)benzoate (VI). The reduction of (VI) with NaBH4 in methanol gives the benzyl alcohol (VII), which is treated with Ms-Cl and triethylamine to yield the mesylate (VIII). The condensation of (VIII) with N-(4-methyl-3-nitropyridin-2-yl)butyramide (IX) by means of NaOH and K2CO3 affords the disubstituted amide (X), which is cyclized by reduction of its nitro group with Fe and AcOH giving the imidazo[4,5-b]pyridine (XI). Finally, this compound is condensed with sodium azide and triethylamine in hot DMI in order to form the tetrazole ring of the target compound, which is salified with HCl in isopropanol/water.
| 【1】 Zanka, A.; et al.; Pilot scale synthesis of a novel nonpeptide angiotensin II receptor antagonist. Org Process Res Dev 1998, 2, 4, 230. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16498 | Benzocaine; ethyl 4-aminobenzoate | 94-09-7 | C9H11NO2 | 详情 | 详情 |
| (II) | 12132 | 2,5-Dimethoxytetrahydrofuran; 5-Methoxytetrahydro-2-furanyl methyl ether | 696-59-3 | C6H12O3 | 详情 | 详情 |
| (III) | 35440 | ethyl 4-(1H-pyrrol-1-yl)benzoate | C13H13NO2 | 详情 | 详情 | |
| (IV) | 35448 | [1-[4-(ethoxycarbonyl)phenyl]-1H-pyrrol-2-yl]-N,N,N-trimethylmethanaminium iodide | C17H23IN2O2 | 详情 | 详情 | |
| (V) | 35441 | ethyl 4-(2-methyl-1H-pyrrol-1-yl)benzoate | C14H15NO2 | 详情 | 详情 | |
| (VI) | 35442 | ethyl 4-(2-cyano-5-methyl-1H-pyrrol-1-yl)benzoate | C15H14N2O2 | 详情 | 详情 | |
| (VII) | 35443 | 1-[4-(hydroxymethyl)phenyl]-5-methyl-1H-pyrrole-2-carbonitrile | C13H12N2O | 详情 | 详情 | |
| (VIII) | 35444 | 5-methyl-1-[4-([[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]methyl)phenyl]-1H-pyrrole-2-carbonitrile | C16H18N2OS | 详情 | 详情 | |
| (IX) | 35445 | N-(4-methyl-3-nitro-2-pyridinyl)butanamide | C10H13N3O3 | 详情 | 详情 | |
| (X) | 35446 | N-[4-(2-cyano-5-methyl-1H-pyrrol-1-yl)benzyl]-N-(4-methyl-3-nitro-2-pyridinyl)butanamide | C23H23N5O3 | 详情 | 详情 | |
| (XI) | 35447 | 5-methyl-1-[4-[(7-methyl-2-propyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-1H-pyrrole-2-carbonitrile | C23H23N5 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(VIII)The condensation of adenine (I) with ethyl acrylate (II) by means of sodium ethoxide in methanol gives 3-(9-adenyl)propionic acid ethyl ester (III), which is treated with NaNO2/acetic acid yielding 3-(6-oxo-1,6-dihydro-9H-purin-9-yl)propionic acid ethyl ester (IV). The hydrolysis of (IV) with KOH in water affords the corresponding free acid (V), which is esterified with 4-chlorophenyl trifluoroacetate (VI) in pyridine giving the expected 4-chlorophenyl ester (VII). The condensation of ester (VII) with ethyl 4-aminobenzoate (VIII) by heating (35-40 C) in DMSO yields 4-[3-(6-oxo-1,6-dihydro-9H-purin-9-yl)propionamido]benzoic acid ethyl ester (IX), which is finally hydrolyzed with KOH in water.
| 【1】 Graul, A.; Castañer, J.; AIT-082. Drugs Fut 1997, 22, 9, 945. |
| 【2】 Glasky, A.J.; Multi-functional pharmaceutical cpds. and methods of use. WO 9114434 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10343 | 9H-Purin-6-amine; 9H-Purin-6-ylamine; Adenine | 73-24-5 | C5H5N5 | 详情 | 详情 |
| (II) | 10164 | ethyl acrylate | 140-88-5 | C5H8O2 | 详情 | 详情 |
| (III) | 16493 | ethyl 3-(6-amino-9H-purin-9-yl)propanoate | C10H13N5O2 | 详情 | 详情 | |
| (IV) | 16494 | ethyl 3-(6-oxo-1,6-dihydro-9H-purin-9-yl)propanoate | C10H12N4O3 | 详情 | 详情 | |
| (V) | 16495 | 3-(6-oxo-1,6-dihydro-9H-purin-9-yl)propionic acid | C8H8N4O3 | 详情 | 详情 | |
| (VI) | 16496 | 4-[(2,2,2-trifluoroacetyl)oxy]benzoic acid | C9H5F3O4 | 详情 | 详情 | |
| (VII) | 16497 | 4-[[3-(6-oxo-1,6-dihydro-9H-purin-9-yl)propanoyl]oxy]benzoic acid | C15H12N4O5 | 详情 | 详情 | |
| (VIII) | 16498 | Benzocaine; ethyl 4-aminobenzoate | 94-09-7 | C9H11NO2 | 详情 | 详情 |
| (IX) | 16499 | ethyl 4-[[3-(6-oxo-1,6-dihydro-9H-purin-9-yl)propanoyl]amino]benzoate | C17H17N5O4 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(V)Methylation of 1,12-dicarba-closo-dodecaborane (I) with methyl triflate at 130 C in a sealed vessel afforded the decamethyl borane (II). Lithiation of (II) with methyllithium and subsequent quenching with CO2 produced the carboxylic acid (III), which was further converted to the corresponding acid chloride (IV) by treatment with SOCl2. Condensation of acid chloride (IV) with ethyl 4-aminobenzoate (V) in o-dichlorobenzene at 180 C gave amide (VI). Finally, basic hydrolysis of the ethyl ester group of (VI) furnished the title carboxylic acid.
| 【1】 Endo, Y.; et al.; Functionalization of polymethylcarboranes. Preparation and reactivity of 2,3,4,5,6,7,8,9,10,11-decamethyl-1,12-dicarba-closo-dodecaborane(12)-1-carboxylic acid. Chem Pharm Bull 1999, 47, 5, 699. |
| 【2】 Kagechika, H.; Yaguchi, K.; Kawachi, E.; Endo, Y.; Polymethylcarborane as a novel biactive moiety: Derivatives with potent retinoid antagonistic activity. Bioorg Med Chem Lett 2000, 10, 15, 1733. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 42007 | 3-[6-(1,2-diboriran-3-yl)hexaboranyl]-1,2-diborirane | C2H12B10 | 详情 | 详情 | |
| (II) | 46964 | 3-[6-(1,2-dimethyl-1,2-diboriran-3-yl)-1,2,3,4,5,6-hexamethylhexaboranyl]-1,2-dimethyl-1,2-diborirane | C12H32B10 | 详情 | 详情 | |
| (III) | 46965 | 3-[6-(1,2-dimethyl-1,2-diboriran-3-yl)-1,2,3,4,5,6-hexamethylhexaboranyl]-1,2-dimethyl-1,2-diborirane-3-carboxylic acid | C13H32B10O2 | 详情 | 详情 | |
| (IV) | 46966 | 3-[6-(1,2-dimethyl-1,2-diboriran-3-yl)-1,2,3,4,5,6-hexamethylhexaboranyl]-1,2-dimethyl-1,2-diborirane-3-carbonyl chloride | C13H31B10ClO | 详情 | 详情 | |
| (V) | 16498 | Benzocaine; ethyl 4-aminobenzoate | 94-09-7 | C9H11NO2 | 详情 | 详情 |
| (VI) | 46967 | ethyl 4-[([3-[6-(1,2-dimethyl-1,2-diboriran-3-yl)-1,2,3,4,5,6-hexamethylhexaboranyl]-1,2-dimethyl-1,2-diboriran-3-yl]carbonyl)amino]benzoate | C22H41B10NO3 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(I)The reaction of 4-aminobenzoic acid ethyl ester (I) with acryloyl chloride (II) by means of TEA in dichloromethane gives the corresponding acrylamide (III), which is condensed with 4,5,6,7-tetrahydro-1H-indol-4-one (IV) by means of K2CO3 in hot DMF to yield NEO-339. (1,2)
| 【1】 Mohan, P.; Fick, D.B.; McKinley, L.K.; Prigaro, B.J.; Pfadenhauer, E.; Helton, D.; Search, design and discovery of NEO-339, a novel agent that increases attentional processes associated with cognition. 224th ACS Natl Meet (Aug 18 2002, Boston) 2002, Abst MEDI 249. |
| 【2】 Foreman, M.M.; Glasky, A.J.; Fick, D.B. (Spectrum Pharmaceuticals, Inc.); Synthesis and methods of use of tetrahydroisoindolone analogues and derivs.. EP 1383742; WO 0285856 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16498 | Benzocaine; ethyl 4-aminobenzoate | 94-09-7 | C9H11NO2 | 详情 | 详情 |
| (II) | 11577 | Acryloyl chloride; Acrylyl chloride;2-Propenoyl chloride | 814-68-6 | C3H3ClO | 详情 | 详情 |
| (III) | 64783 | ethyl 4-(acryloylamino)benzoate | C12H13NO3 | 详情 | 详情 | |
| (IV) | 64784 | ethyl 2-[2,3-dihydro-1,4-benzodioxin-5-yl(2-ethoxy-2-oxoethyl)amino]acetate | C16H21NO6 | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(XIV)The condensation of 3-ethylphenol (I) with 4-piperidone (II) by means of gaseous HCl in acetic acid gives 5-ethyl-2-(1,2,3,6-tetrahydropyridin-4-yl)phenol (III), which is treated with acetic anhydride in pyridine to yield the diacetyl derivative (IV). The selective hydrolysis of the O-acetyl group of (IV) by means of K2CO3 in methanol affords the phenol derivative (V), which is hydrogenated with H2 over Pd/C in methanol to provide the acetyl piperidine (VI). The alkylation of the phenolic group of (VI) with ethyl iodide and Cs2CO3 in refluxing acetone gives 1-acetyl-4-(2-ethoxy-4-ethylphenyl)piperidine (VII), which is deacetylated by means of NaOH in refluxing methanol to yield 4-(2-ethoxy-4-ethylphenyl)piperidine (VIII). The alkylation of the piperidine (VIII) with N-(4-bromobutyl)phthalimide (IX) by means of Cs2CO3 in refluxing acetone affords the adduct (X), which is cleaved with hydrazine in hot methanol to provide 1-(4-aminobutyl)-4-(2-ethoxy-4-ethylphenyl)piperidine (XI). Finally, this amine is condensed with 4-(4-chlorobenzamido)benzoic acid (XII) by means of EDC, HOBT and TEA in DMF to give the target diamide. The intermediate 4-(4-chlorobenzamido)benzoic acid (XII) is obtained as follows: The condensation of 4-aminobenzoic acid ethyl ester (XIV) with 4-chlorobenzoyl chloride (XIII) by means of TEA and DMAP gives 4-(4-chlorobenzamido)benzoic acid ethyl ester (XV), which is finally hydrolyzed with NaOH to afford the target benzoic acid intermediate (XII).
| 【1】 Grand-Perret, T.A.R.; Issandou, M. (GlaxoSmithKline plc); Binding competition of SREBP-cleavage activating protein (SCAP) antagonists. WO 0106261 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 53495 | 3-Ethyl phenol; m-Ethyl phenol | 620-17-7 | C8H10O | 详情 | 详情 |
| (II) | 27115 | 4-piperidinone | 40064-34-4 | C5H9NO | 详情 | 详情 |
| (III) | 53496 | 5-ethyl-2-(1,2,3,6-tetrahydro-4-pyridinyl)phenol | n/a | C13H17NO | 详情 | 详情 |
| (IV) | 53497 | 2-(1-acetyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-ethylphenyl acetate | n/a | C17H21NO3 | 详情 | 详情 |
| (V) | 53498 | 1-[4-(4-ethyl-2-hydroxyphenyl)-3,6-dihydro-1(2H)-pyridinyl]-1-ethanone | n/a | C15H19NO2 | 详情 | 详情 |
| (VI) | 53499 | 1-[4-(4-ethyl-2-hydroxyphenyl)-1-piperidinyl]-1-ethanone | n/a | C15H21NO2 | 详情 | 详情 |
| (VII) | 53500 | 1-[4-(2-ethoxy-4-ethylphenyl)-1-piperidinyl]-1-ethanone | n/a | C17H25NO2 | 详情 | 详情 |
| (VIII) | 53501 | 4-(2-ethoxy-4-ethylphenyl)piperidine; ethyl 5-ethyl-2-(4-piperidinyl)phenyl ether | n/a | C15H23NO | 详情 | 详情 |
| (IX) | 17163 | N-(4-Bromobutyl)phthalimide; 2-(4-Bromobutyl)-1H-isoindole-1,3(2H)-dione | 5394-18-3 | C12H12BrNO2 | 详情 | 详情 |
| (X) | 53502 | 2-{4-[4-(2-ethoxy-4-ethylphenyl)-1-piperidinyl]butyl}-1H-isoindole-1,3(2H)-dione | n/a | C27H34N2O3 | 详情 | 详情 |
| (XI) | 53503 | 4-[4-(2-ethoxy-4-ethylphenyl)-1-piperidinyl]-1-butanamine; 4-[4-(2-ethoxy-4-ethylphenyl)-1-piperidinyl]butylamine | n/a | C19H32N2O | 详情 | 详情 |
| (XII) | 53504 | 4-[(4-chlorobenzoyl)amino]benzoic acid | n/a | C14H10ClNO3 | 详情 | 详情 |
| (XIII) | 10295 | p-Chlorobenzoyl chloride; 4-Chlorobenzoyl chloride | 122-01-0 | C7H4Cl2O | 详情 | 详情 |
| (XIV) | 16498 | Benzocaine; ethyl 4-aminobenzoate | 94-09-7 | C9H11NO2 | 详情 | 详情 |
| (XV) | 53505 | Ethyl 4-(4-chlorobenzamido)benzoate | n/a | C16H14ClNO3 | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(I)Reaction of ethyl 4-aminobenzoate (I) with sodium thiocyanate and bromine in cold AcOH gives rise to the amino benzothiazole (II). Subsequent treatment of (II) with phenyl chloroformate affords the phenyl carbamate (III), which is further reacted with tert-butylamine to furnish urea (IV). After alkaline hydrolysis of the ethyl ester (IV), the resultant carboxylic acid (V) is converted to the azabenzotriazolyl active ester (VI) upon treatment with HATU in DMF. Active ester (VI) is finally coupled with 2-chloro-6-methylaniline (VII) in the presence of sodium bis(trimethylsilyl)amide to yield the target amide.
| 【1】 Das, J.; Barrish, J.C.; Wityak, J. (Bristol-Myers Squibb Co.); Benzothiazole protein tyrosine kinase inhibitors. EP 1037632; JP 2001522800; WO 9924035 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16498 | Benzocaine; ethyl 4-aminobenzoate | 94-09-7 | C9H11NO2 | 详情 | 详情 |
| (II) | 65034 | ethyl 2-amino-1,3-benzothiazole-6-carboxylate | C10H10N2O2S | 详情 | 详情 | |
| (III) | 65035 | ethyl 2-[(phenoxycarbonyl)amino]-1,3-benzothiazole-6-carboxylate | C17H14N2O4S | 详情 | 详情 | |
| (IV) | 65036 | ethyl 2-{[(tert-butylamino)carbonyl]amino}-1,3-benzothiazole-6-carboxylate | C15H19N3O3S | 详情 | 详情 | |
| (V) | 65037 | 2-{[(tert-butylamino)carbonyl]amino}-1,3-benzothiazole-6-carboxylic acid | C13H15N3O3S | 详情 | 详情 | |
| (VI) | 65038 | N-(tert-butyl)-N'-{6-[(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)carbonyl]-1,3-benzothiazol-2-yl}urea | C18H17N7O3S | 详情 | 详情 | |
| (VII) | 29789 | 2-chloro-6-methylphenylamine; 2-chloro-6-methylaniline | 87-63-8 | C7H8ClN | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(I)In an alternative method, ethyl 4-aminobenzoate (I) is treated with NaSCN/Br2 to produce the amino benzothiazole (II), which is further protected as the N-Boc derivative (III). Alkaline hydrolysis of ester (III), followed by chlorination of the resultant acid (IV) with oxalyl chloride gives rise to the acid chloride (V). This is then coupled with 2-chloro-6-methylaniline (VI) yielding amide (VII). The N-Boc protecting group of (VII) is then cleaved employing trifluoroacetic acid to produce amine (VIII), which is subsequently reacted with phenyl chloroformate producing the phenyl carbamate (IX). Finally, displacement of carbamate (IX) with tert-butylamine furnishes the title urea. (1,2)
| 【1】 Das, J.; Lin, J.; Moquin, R.V.; Shen, Z.; Spergel, S.H.; Wityak, J.; Doweyko, A.M.; DeFex, H.F.; Fang, Q.; Pang, S.; Pitt, S.; Shen, D.R.; Schieven, G.L.; Barrish, J.C.; Molecular design, synthesis, and structure-activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117. Bioorg Med Chem Lett 2003, 13, 13, 2145. |
| 【2】 Das, J.; Barrish, J.C.; Wityak, J. (Bristol-Myers Squibb Co.); Benzothiazole protein tyrosine kinase inhibitors. EP 1037632; JP 2001522800; WO 9924035 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16498 | Benzocaine; ethyl 4-aminobenzoate | 94-09-7 | C9H11NO2 | 详情 | 详情 |
| (II) | 65034 | ethyl 2-amino-1,3-benzothiazole-6-carboxylate | C10H10N2O2S | 详情 | 详情 | |
| (III) | 65039 | ethyl 2-[(tert-butoxycarbonyl)amino]-1,3-benzothiazole-6-carboxylate | C15H18N2O4S | 详情 | 详情 | |
| (IV) | 65040 | 2-[(tert-butoxycarbonyl)amino]-1,3-benzothiazole-6-carboxylic acid | C13H14N2O4S | 详情 | 详情 | |
| (V) | 65041 | tert-butyl 6-(chlorocarbonyl)-1,3-benzothiazol-2-ylcarbamate | C13H13ClN2O3S | 详情 | 详情 | |
| (VI) | 29787 | 2-(3-methyl-4-oxo-1,3-thiazolidin-2-ylidene)acetyl chloride | C6H6ClNO2S | 详情 | 详情 | |
| (VII) | 65042 | tert-butyl 6-[(2-chloro-6-methylanilino)carbonyl]-1,3-benzothiazol-2-ylcarbamate | C20H20ClN3O3S | 详情 | 详情 | |
| (VIII) | 65043 | 2-amino-N-(2-chloro-6-methylphenyl)-1,3-benzothiazole-6-carboxamide | C15H12ClN3OS | 详情 | 详情 | |
| (IX) | 65044 | phenyl 6-[(2-chloro-6-methylanilino)carbonyl]-1,3-benzothiazol-2-ylcarbamate | C22H16ClN3O3S | 详情 | 详情 |