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【结 构 式】

【分子编号】16440

【品名】1-benzyl-2,5-bis(trimethylsilyl)pyrrolidine

【CA登记号】

【 分 子 式 】C17H31NSi2

【 分 子 量 】305.61088

【元素组成】C 66.81% H 10.22% N 4.58% Si 18.38%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(LXX)

17) Pandey et al. reported an efficient synthesis of epibatidine via [3+2] cycloaddition of nonstabilized azomethine ylide and substituted 6-chloro-3-vinylpyridine. The precursor (LXX) was obtained in 73% yield from N-BOC pyrrolidine (LXIX) by standard manipulations. The [3+2] cycloaddition between (LXX) and alpha,beta-unsaturated ester (LXXI) furnished cycloadduct (LXXII) stereoselectively. Decarboxylation followed by reductive N-debenzylation converted (LXXII) into (I) in 78% overall yield.

1 Bai, D.; Xu, R.; Zhu, X.; Epibatidine. Drugs Fut 1997, 22, 11, 1210.
2 Pandey, G.; Bagul, T.D.; Lakshmaiah, G.; An expeditious synthesis of epibatidine and analogues. Tetrahedron Lett 1994, 35, 7439-42.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
rac-(LXXII) 16442 2-[(1S,2S,3R,4R)-7-benzyl-3-(6-chloro-3-pyridinyl)-7-azabicyclo[2.2.1]hept-2-yl]ethyl formate C21H23ClN2O2 详情 详情
(LXIX) 16439 tert-butyl 1-pyrrolidinecarboxylate 86953-79-9 C9H17NO2 详情 详情
(LXX) 16440 1-benzyl-2,5-bis(trimethylsilyl)pyrrolidine C17H31NSi2 详情 详情
(LXXI) 16441 ethyl (E)-3-(6-chloro-3-pyridinyl)-2-propenoate C10H10ClNO2 详情 详情
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