【结 构 式】 |
【分子编号】16284 【品名】5-(2-bromoethyl)-6-chloro-1,3-dihydro-2H-indol-2-one 【CA登记号】 |
【 分 子 式 】C10H9BrClNO 【 分 子 量 】274.5443 【元素组成】C 43.75% H 3.3% Br 29.1% Cl 12.91% N 5.1% O 5.83% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)A new synthesis for ziprasidone hydrochloride has been reported: The condensation of 6-chloroindolin-2-one (I) with bromoacetic acid (II) by means of polyphosphoric acid (PPA) gives 5-(bromoacetyl)-6-chloroindolin-2-one (III), which is reduced with triethylsilane and trifluoroacetic acid to the corresponding 2-bromoethyl derivative (IV). Finally, this compound is condensed with 4-(3-benzisothiazolyl)piperazine (V) by means of Na2CO3 in DMF or isobutyl methyl ketone.
【1】 Howard, H.R.; Lowe, J.A. III, Seeger, T.F.; et al.; 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents. J Med Chem 1996, 39, 1, 143. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 16275 | 6-chloro-1,3-dihydro-2H-indol-2-one | 56341-37-8 | C8H6ClNO | 详情 | 详情 |
(II) | 23660 | 2-Bromoacetic acid | 79-08-3 | C2H3BrO2 | 详情 | 详情 |
(III) | 16283 | 5-(2-bromoacetyl)-6-chloro-1,3-dihydro-2H-indol-2-one | C10H7BrClNO2 | 详情 | 详情 | |
(IV) | 16284 | 5-(2-bromoethyl)-6-chloro-1,3-dihydro-2H-indol-2-one | C10H9BrClNO | 详情 | 详情 | |
(V) | 16280 | 3-piperazino-1,2-benzisothiazole; 1,2-Benzisothiazole-3-(1-piperazinyl) | 87691-87-0 | C11H13N3S | 详情 | 详情 |
Extended Information