(2R,3R,4S)-3-(acetamido)-4-(cyanoamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid -Drug Synthesis Database

【结构式】

【分子编号】15991

【品名】(2R,3R,4S)-3-(acetamido)-4-(cyanoamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid

【CA登记号】

【分子式】C₁₂H₁₇N₃O₇

【分子量】315.283

【元素组成】C 45.72% H 5.43% N 13.33% O 35.52%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The synthesis of [11C]-labeled zanamivir useful in PET studies of drug deposition has been reported: The reaction of the known amino acid GR-121158X (I) with [11C]-cyanogen bromide in 0.1 M sodium borate gives the cyanoamino derivative (II), which is finally treated with a hot solution of NH4Cl and NH4OH in water.

参考文献中间体

合成目标

【1】 Sutherland, D.R.; Westerberg, G.; Bamford, M.; Langstrom, B.; Daniel, M.J.; Synthesis of 5-acetylamino-4-[C-11]guanidino-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enoic acid ([C-11]GG167) - An influenza virus neuraminidase inhibitor. J Label Compd Radiopharm 1996, 38, 6, 585.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	15981	(2R,3R,4S)-3-(acetamido)-4-amino-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid	C₁₁H₁₈N₂O₇	详情	详情
(II)	15982	(2R,3R,4S)-3-(acetamido)-4-(cyanoamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid	C₁₂H₁₇N₃O₇	详情	详情
(II)	15991	(2R,3R,4S)-3-(acetamido)-4-(cyanoamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid	C₁₂H₁₇N₃O₇	详情	详情

Extended Information