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【结 构 式】 
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【分子编号】15767 【品名】N-Methylamylamine; N-methyl-N-pentylamine; N-methyl-1-pentanamine 【CA登记号】25419-06-1 |
【 分 子 式 】C6H15N 【 分 子 量 】101.19184 【元素组成】C 71.22% H 14.94% N 13.84% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(IV)Starting from N-pentylamine (I), the intermediate N-methyl-N-pentylamine (IV) is condensed with methyl methacrylate to give N-methyl-N-pentyl-beta-alanine methyl ester (V). After hydrolysis of the methyl ester (V), the bisphosphonate is produced in the common way using phosphorous oxychloride/phosphorous acid.
| 【1】 Muhlbauer, R.C.; Bauss, F.; BM-21.0955, Monosodium Salt, Monohydrate. Drugs Fut 1994, 19, 1, 13. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 15764 | amylamine; 1-pentanamine; pentylamine | 110-58-7 | C5H13N | 详情 | 详情 |
| (II) | 10498 | Benzaldehyde;Benzoic aldehyde;Phenylmethanal | 100-52-7 | C7H6O | 详情 | 详情 |
| (III) | 15766 | N-pentyl-N-[(E)-benzylidene]amine; N-[(E)-benzylidene]-1-pentanamine | C12H17N | 详情 | 详情 | |
| (IV) | 15767 | N-Methylamylamine; N-methyl-N-pentylamine; N-methyl-1-pentanamine | 25419-06-1 | C6H15N | 详情 | 详情 |
| (V) | 15768 | methyl 3-[methyl(pentyl)amino]propanoate | C10H21NO2 | 详情 | 详情 | |
| (VI) | 15769 | 3-[methyl(pentyl)amino]propionic acid | C9H19NO2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(IV)
| 【1】 Baetz F,JunghansB 2006. Improved process for the preparation of sodium ibandronate, [l-hydroxy-3-(methylpentylamino) propylidene] bisphosphonic acid monosodium salt mmohydrate W0 2006045578（本专利申请人为F．Hoffmann-IA Roche AG, Switz） |
| 【2】 Grassi S,Volante A. 2005. An improved process for the preparation of alkyl- and aryl-substituted-hydroxy-l,l-ethanediphosphonic acids and salts thereof by solvent-free reaction of carboxylic acids with pbosphoxous acid and phosphorus oxychloride. W0 2005063779(本专利申请人为Lyogen Limited, Cyprus) |
| 【3】 Szabo CM, Matsumura Y, Fukrua S,et aL 2002. Inhibition of geranylgeranyl diphosphate synthase by bisphosphontes and diphosphates: a potential route to new bone antiresorption ru,d antiparasitic agents.J Med Che:m, 45 (11): 2185~2196 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 15764 | amylamine; 1-pentanamine; pentylamine | 110-58-7 | C5H13N | 详情 | 详情 |
| (II) | 10498 | Benzaldehyde;Benzoic aldehyde;Phenylmethanal | 100-52-7 | C7H6O | 详情 | 详情 |
| (III) | 15766 | N-pentyl-N-[(E)-benzylidene]amine; N-[(E)-benzylidene]-1-pentanamine | C12H17N | 详情 | 详情 | |
| (IV) | 15767 | N-Methylamylamine; N-methyl-N-pentylamine; N-methyl-1-pentanamine | 25419-06-1 | C6H15N | 详情 | 详情 |
Extended Information