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【结 构 式】 
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【分子编号】15747 【品名】N-[(1-[[(dimethylamino)oxy]sulfinyl]-5-methyl-1H-imidazol-4-yl)methyl]-2-(3-iodo-1-methyl-1H-indol-2-yl)-1-ethanamine; N-[(1-[[(dimethylamino)oxy]sulfinyl]-5-methyl-1H-imidazol-4-yl)methyl]-N-[2-(3-iodo-1-methyl-1H-indol-2-yl)ethyl]amine 【CA登记号】 |
【 分 子 式 】C18H24IN5O2S 【 分 子 量 】501.39153 【元素组成】C 43.12% H 4.82% I 25.31% N 13.97% O 6.38% S 6.4% |
合成路线1
该中间体在本合成路线中的序号：(XV)4) Treatment of the 2-substituted indole (XII) with iodine and potassium iodide in aqueous solution in the presence of potassium carbonate yields the corresponding 3-iodo derivative (XIV). Hydrolysis of the trifluoroacetyl group with aqueous potassium carbonate gives the amino derivative (XV), which undergoes a palladium-catalyzed carbonylation reaction to form the lactam. Finally, the protecting group is removed with hydrochloric acid.
| 【1】 Oxford, A.W.; Hagan, R.M.; Tyers, M.B.; Kilpatrick, G.J.; North, P.C.; GR-68755 Hydrochloride. Drugs Fut 1992, 17, 8, 660. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XII) | 15744 | N-[(1-[[(dimethylamino)oxy]sulfinyl]-5-methyl-1H-imidazol-4-yl)methyl]-2,2,2-trifluoro-N-[2-(1-methyl-1H-indol-2-yl)ethyl]acetamide | C20H24F3N5O3S | 详情 | 详情 | |
| (XIV) | 15746 | N-[(1-[[(dimethylamino)oxy]sulfinyl]-5-methyl-1H-imidazol-4-yl)methyl]-2,2,2-trifluoro-N-[2-(3-iodo-1-methyl-1H-indol-2-yl)ethyl]acetamide | C20H23F3IN5O3S | 详情 | 详情 | |
| (XV) | 15747 | N-[(1-[[(dimethylamino)oxy]sulfinyl]-5-methyl-1H-imidazol-4-yl)methyl]-2-(3-iodo-1-methyl-1H-indol-2-yl)-1-ethanamine; N-[(1-[[(dimethylamino)oxy]sulfinyl]-5-methyl-1H-imidazol-4-yl)methyl]-N-[2-(3-iodo-1-methyl-1H-indol-2-yl)ethyl]amine | C18H24IN5O2S | 详情 | 详情 |