• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】15742

【品名】2-(1-methyl-1H-indol-2-yl)ethylamine; 2-(1-methyl-1H-indol-2-yl)-1-ethanamine

【CA登记号】

【 分 子 式 】C11H14N2

【 分 子 量 】174.24564

【元素组成】C 75.82% H 8.1% N 16.08%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(X)

3) Treatment of 2-(1-methylindol-2-yl)ethanamine (X) in dichloromethane with trifluoroacetic anhydride and triethylamine yields the trifluoroacetamide (XI). This is alkylated with the chloromethylimidazole (IV) to give (XII) and then treated with aqueous potassium carbonate to generate the amino derivative (XIII). Finally, the reaction of (XIII) with phosgene and aluminum chloride in methylene chloride effects acylation and cyclization with concomitant removal of the protecting group.

1 Oxford, A.W.; Hagan, R.M.; Tyers, M.B.; Kilpatrick, G.J.; North, P.C.; GR-68755 Hydrochloride. Drugs Fut 1992, 17, 8, 660.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(X) 15742 2-(1-methyl-1H-indol-2-yl)ethylamine; 2-(1-methyl-1H-indol-2-yl)-1-ethanamine C11H14N2 详情 详情
(XI) 15743 2,2,2-trifluoro-N-[2-(1-methyl-1H-indol-2-yl)ethyl]acetamide C13H13F3N2O 详情 详情
(XII) 15744 N-[(1-[[(dimethylamino)oxy]sulfinyl]-5-methyl-1H-imidazol-4-yl)methyl]-2,2,2-trifluoro-N-[2-(1-methyl-1H-indol-2-yl)ethyl]acetamide C20H24F3N5O3S 详情 详情
(XIII) 15745 N-[(1-[[(dimethylamino)oxy]sulfinyl]-5-methyl-1H-imidazol-4-yl)methyl]-N-[2-(1-methyl-1H-indol-2-yl)ethyl]amine; N-[(1-[[(dimethylamino)oxy]sulfinyl]-5-methyl-1H-imidazol-4-yl)methyl]-2-(1-methyl-1H-indol-2-yl)-1-ethanamine C18H25N5O2S 详情 详情
Extended Information