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【结 构 式】 
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【分子编号】15205 【品名】(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl 4-methylbenzenesulfonate 【CA登记号】 |
【 分 子 式 】C16H16O5S 【 分 子 量 】320.36604 【元素组成】C 59.99% H 5.03% O 24.97% S 10.01% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Condensation of 2(R)-(tosyloxymethyl)-1,4-benzodioxane (I) with 5-(3-aminopropoxy)-1,3-benzodioxole (II) by means of triethylamine in refluxing acetonitrile, followed by salification with HCl in ethyl acetate/isopropanol. (1,2)
| 【1】 Tracy, M.; Castaner, J.; Prous, J.; MKC-242. Drugs Fut 1997, 22, 3, 225. |
| 【2】 Iwata, H.; Baba, A.; Matsuda, T.; Egawa, M.; Tobe, A.; Saito, K. (Mitsubishi Chemical Corp.); Optically active alkylene-dioxybenzene derivs. and their use in therapy. EP 0446921; JP 1991264528; US 5168099; US 5234948 . |
| 【3】 Iwata, H.; Bab, A.; Matsuda T.; Egawa, M.; Tobe, A.; Saito, K. (Institut Pasteur); Alkylenedioxybenzene derivs. and anxiolytic agent containing them. EP 0139555; ES 8608046; JP 1985155195; US 4686281 . |
Extended Information