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【结 构 式】 
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【分子编号】15108 【品名】7-bromo-1-cyclopropyl-6-fluoro-5-(hydroxymethyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid 【CA登记号】 |
【 分 子 式 】C14H11BrFNO4 【 分 子 量 】356.1480832 【元素组成】C 47.21% H 3.11% Br 22.44% F 5.33% N 3.93% O 17.97% |
合成路线1
该中间体在本合成路线中的序号：(XVI)5) Compound (XVIII): The esterification of 7-bromo-1-cyclopropyl-6-fluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-ca rboxylic acid (XII) with SOCl2/methanol gives the corresponding methyl ester (XIII), which is brominated with N-bromosuccinimide (NBS) and benzoyl peroxide (BPO) in refluxing CCl4 yielding the corresponding bromomethyl derivative (XIV). The reaction of (XIV) with sodium acetate in hot DMF affords the expected acetoxymethyl derivative (XV), which is saponified with K2CO3 in methanol/water to give 1-cyclopropyl-6-fluoro-5-(hydroxymethyl)-4-oxo-1,4-dihydroquinoline-3-c arboxylic acid (XVI). Finally, this compound is condensed with 2-methylpiperazine (XVII) by heating at 110 C. 6) Compound (XX): The condensation of the hydroxymethylquinolone (XVI) with the benzylamine (VI) as before gives 6-fluoro-5-(hydroxymethyl)-4-(4-methoxybenzylamino)-4-oxo-1,4-dihydroqu inoline-3-carboxylic acid (XIX), which is then debenzylated with trifluoroacetic acid an H2SO4 as before.
| 【1】 Otsubo, K.; Kawano, Y.; Ohguro, K.; Uchida, M.; Ohtani, T.; Ohmori, K.; Matsubara, J.; Morita, S.; Synthesis of possible metabolites of 1-cyclopropyl-1,4-dihydro-6-fluoro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid (grepafloxacin, OPC-17116). Chem Pharm Bull 1995, 43, 12, 2246. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 15098 | 4-Methoxybenzylamine; (4-Methoxyphenyl)methanamine | 2393-23-9 | C8H11NO | 详情 | 详情 |
| (XII) | 15104 | 7-bromo-1-cyclopropyl-6-fluoro-5-methyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C14H11BrFNO3 | 详情 | 详情 | |
| (XIII) | 15105 | methyl 7-bromo-1-cyclopropyl-6-fluoro-5-methyl-4-oxo-1,4-dihydro-3-quinolinecarboxylate | C15H13BrFNO3 | 详情 | 详情 | |
| (XIV) | 15106 | methyl 7-bromo-5-(bromomethyl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate | C15H12Br2FNO3 | 详情 | 详情 | |
| (XV) | 15107 | methyl 5-[(acetoxy)methyl]-7-bromo-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate | C17H15BrFNO5 | 详情 | 详情 | |
| (XVI) | 15108 | 7-bromo-1-cyclopropyl-6-fluoro-5-(hydroxymethyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C14H11BrFNO4 | 详情 | 详情 | |
| (XVII) | 12267 | 2-Methylpiperazine | 109-07-9 | C5H12N2 | 详情 | 详情 |
| (XVIII) | 15110 | 1-cyclopropyl-6-fluoro-5-(hydroxymethyl)-7-(3-methylpiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C19H22FN3O4 | 详情 | 详情 | |
| (XIX) | 15111 | 1-cyclopropyl-6-fluoro-5-(hydroxymethyl)-7-[(4-methoxybenzyl)amino]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C22H21FN2O5 | 详情 | 详情 | |
| (XX) | 15112 | 7-amino-1-cyclopropyl-6-fluoro-5-(hydroxymethyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C14H13FN2O4 | 详情 | 详情 |