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【结 构 式】 
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【分子编号】67705 【品名】cyclopropyl isocyanate 【CA登记号】4747-72-2 |
【 分 子 式 】C4H5NO 【 分 子 量 】83.09 【元素组成】C 57.82% H 6.07% N 16.86% O 19.26% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)Lenvatinib is prepared by condensation of 4-chloro-7-methoxyquinoline-6-carbonitrile (I) with 3-chloro-4-nitrophenol (II) in hot 2,6-lutidine to afford the 4-aryloxy quinoline (III), which by reduction of its nitro group by means of iron and ammonium chloride yields aniline (IV). Aniline (IV) is then condensed with cyclopropyl isocyanate (V), producing urea (VI), which is finally submitted to partial hydrolysis of the nitrile group under basic conditions .
| 【1】 Funahashi, Y., Arimoto, I., Matsukura, M. et al. (Eisai R&D Management Co., Ltd.). Nitrogenous aromatic ring compounds. CA 2426461, EP 1415987, EP1506962, EP 1777218, JP 2005272474, JP 2009215313, US 2004953908, US 2006160832, US 2006247259, US 7253286, US 7612092, US 2010197911, US 2011118470, US 7973160, US 8372981, WO 2002032872. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 67702 | 4-chloro-7-methoxyquinoline-6-carbonitrile | C11H7ClN2O | 详情 | 详情 | |
| (II) | 12599 | 3-Chloro-4-nitrophenol | 491-11-2 | C6H4ClNO3 | 详情 | 详情 |
| (III) | 67703 | 4-(3-chloro-4-nitrophenoxy)-7-methoxyquinoline-6-carbonitrile | C17H10ClN3O4 | 详情 | 详情 | |
| (IV) | 67704 | 4-(4-amino-3-chlorophenoxy)-7-methoxyquinoline-6-carbonitrile | C17H12ClNO2 | 详情 | 详情 | |
| (V) | 67705 | cyclopropyl isocyanate | 4747-72-2 | C4H5NO | 详情 | 详情 |
| (VI) | 67706 | 1-(2-chloro-4-((6-cyano-7-methoxyquinolin-4-yl)oxy)phenyl)-3-cyclopropylurea | C21H17ClN4O3 | 详情 | 详情 |
Extended Information