【结 构 式】 |
【分子编号】14840 【品名】methyl 2-(2-[(2S,3aR,4R,5S,6aR)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-[(E,3R,5S)-3-hydroxy-5-methyl-1-nonenyl]octahydro-2-pentalenyl]ethoxy)acetate 【CA登记号】 |
【 分 子 式 】C29H54O5Si 【 分 子 量 】510.83026 【元素组成】C 68.19% H 10.65% O 15.66% Si 5.5% |
合成路线1
该中间体在本合成路线中的序号:(XXIIIa)The reduction of the enone (I) with Red Al or NaBH4 gives the corresponding alcohol (XIV), which is mesylated with methanesulfonyl chloride to the ester (XV). The condensation of (XV) with dimethyl malonate by means of NaH in toluene/methanol yields the malonic derivative (XVI), which is submitted to hydrolysis with KOH and partial decarboxylation in refluxing toluene to afford the substituted acetic acid (XVII). This compound is then reduced with Red Al or LiAlH4 to the ethanol derivative (IV), already obtained. The condensation of (IV) with sodium chloroacetate by means of BuLi in DMSO, followed by esterification with methanol in H2SO4 gives the ethoxyacetic ester (XVIII), which is treated with H2O2 and Na2WO4 in dichloromethane/water with a phase-transfer agent in order to obtain the epoxide (XIX). The cleavage of (XIX) with HIO4 in the same solvent mixture affords the dialdehyde (XX), which is submitted to an aldol condensation by means of piperidine/acetic acid, yielding a mixture of two hydroxy aldehydes (XXIa and XXIb). This mixture is submitted to a Wittig condensation with the phosphonate (X), already used, and a mixture of two isomeric hydroxy ketones (XXIIa and XXIIb) is obtained. The free hydroxy group of (XXIIa and XXIIb) is protected with tert-butyldimethylsilyl chloride, and then the oxo group is reduced with NaBH4 and CeCl3 to obtain the mixture of unsaturated alcohols (XXIIIa and XXIIIb).
【1】 Mealy, N.; Castaner, J.; Pimilprost. Drugs Fut 1996, 21, 4, 369. |
【2】 Muraoka, M.; Nakamura, T.; Sugie, A.; Ono, K.; Yamamoto, M. (Sumitomo Pharmaceuticals Co., Ltd.); Bicyclooctane derivs. and their production and use. EP 0115954 . |
【3】 Kawakami, H.; Muraoka, M.; Sugie, A.; Ono, K.; Kojima, A.; Syntheses of new 3-oxa-methano-PGI1 derivatives and their biological properties. Bioorg Med Chem Lett 1993, 3, 12, 2821-6. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
19373 | dimethyl malonate;Methyl malonate;Propanedioic acid dimethyl ester | 108-59-8 | C5H8O4 | 详情 | 详情 | |
63845 | sodium 2-chloroacetate | C2H2ClNaO2 | 详情 | 详情 | ||
(XXIa) | 14836 | methyl 2-[2-[(2S,3aR,4S,5S,6aR)-4-formyl-5-hydroxyoctahydro-2-pentalenyl]ethoxy]acetate | C14H22O5 | 详情 | 详情 | |
(XXIb) | 14837 | methyl 2-[2-[(2R,3aS,4R,5R,6aS)-4-formyl-5-hydroxyoctahydro-2-pentalenyl]ethoxy]acetate | C14H22O5 | 详情 | 详情 | |
(XXIIa) | 14838 | methyl 2-(2-[(2S,3aR,4R,5S,6aR)-5-hydroxy-4-[(E,5S)-5-methyl-3-oxo-1-nonenyl]octahydro-2-pentalenyl]ethoxy)acetate | C23H38O5 | 详情 | 详情 | |
(XXIIb) | 14839 | methyl 2-(2-[(2R,3aS,4S,5R,6aS)-5-hydroxy-4-[(E,5S)-5-methyl-3-oxo-1-nonenyl]octahydro-2-pentalenyl]ethoxy)acetate | C23H38O5 | 详情 | 详情 | |
(XXIIIa) | 14840 | methyl 2-(2-[(2S,3aR,4R,5S,6aR)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-[(E,3R,5S)-3-hydroxy-5-methyl-1-nonenyl]octahydro-2-pentalenyl]ethoxy)acetate | C29H54O5Si | 详情 | 详情 | |
(XXIIIb) | 14841 | methyl 2-(2-[(2R,3aS,4S,5R,6aS)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-[(E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]octahydro-2-pentalenyl]ethoxy)acetate | C29H54O5Si | 详情 | 详情 | |
(I) | 14816 | (3aR,7aS)-1,3,3a,4,7,7a-hexahydro-2H-inden-2-one | C9H12O | 详情 | 详情 | |
(IV) | 14819 | 2-[(3aR,7aS)-2,3,3a,4,7,7a-hexahydro-1H-inden-2-yl]-1-ethanol | C11H18O | 详情 | 详情 | |
(X) | 14825 | dimethyl (4S)-4-methyl-2-oxooctylphosphonate | C11H23O4P | 详情 | 详情 | |
(XIV) | 14829 | (3aR,7aS)-2,3,3a,4,7,7a-hexahydro-1H-inden-2-ol | C9H14O | 详情 | 详情 | |
(XV) | 14830 | (3aR,7aS)-2,3,3a,4,7,7a-hexahydro-1H-inden-2-yl methanesulfonate | C10H16O3S | 详情 | 详情 | |
(XVI) | 14831 | dimethyl 2-[(3aR,7aS)-2,3,3a,4,7,7a-hexahydro-1H-inden-2-yl]malonate | C14H20O4 | 详情 | 详情 | |
(XVII) | 14832 | 2-[(3aR,7aS)-2,3,3a,4,7,7a-hexahydro-1H-inden-2-yl]acetic acid | C11H16O2 | 详情 | 详情 | |
(XVIII) | 14833 | methyl 2-[2-[(3aR,7aS)-2,3,3a,4,7,7a-hexahydro-1H-inden-2-yl]ethoxy]acetate | C14H22O3 | 详情 | 详情 | |
(XIX) | 14834 | methyl 2-[2-[(2aR,5aS)octahydro-1aH-indeno[5,6-b]oxiren-4-yl]ethoxy]acetate | C14H22O4 | 详情 | 详情 | |
(XX) | 14835 | methyl 2-[2-[(3R,4S)-3,4-bis(2-oxoethyl)cyclopentyl]ethoxy]acetate | C14H22O5 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号:(XXIIIa)This new mixture is submitted to a selective epoxidation with (-)-DIPT, titanium tetraisopropoxide and TBHP in order to obtain a mixture of the epoxy alcohol (XXIVa) and the unsaturated alcohol (XXIVb). A chromatographic separation of the mixture followed by desilylation with acetic acid in methanol gives the desired final product.
【1】 Mealy, N.; Castaner, J.; Pimilprost. Drugs Fut 1996, 21, 4, 369. |
【2】 Shimoju. T.; Tanno, N. (Sumitomo Pharmaceuticals Co., Ltd.); Manufacturing method of optically active carbacyclin derivs. JP 1991220158 . |
【3】 Muraoka, M.; Nakamura, T.; Sugie, A.; Ono, K.; Yamamoto, M. (Sumitomo Pharmaceuticals Co., Ltd.); Bicyclooctane derivs. and their production and use. EP 0115954 . |
【4】 Kawakami, H.; Muraoka, M.; Sugie, A.; Ono, K.; Kojima, A.; Syntheses of new 3-oxa-methano-PGI1 derivatives and their biological properties. Bioorg Med Chem Lett 1993, 3, 12, 2821-6. |
【5】 Kawakami, H.; Kojima, A.; Shimoju, T.; Shimaji, K.; Nagata, H.; Muraoka, M.; Tanno, N.; Synthesis and structure-activity relationships of SM-10902, a novel drug for the treatment of peripheral circulatory insufficiency. 111th Annu Meet Pharmaceut Soc Jpn (March 28-30, Tokyo) 1991, Abst 29V 1-036. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(XXIIIa) | 14840 | methyl 2-(2-[(2S,3aR,4R,5S,6aR)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-[(E,3R,5S)-3-hydroxy-5-methyl-1-nonenyl]octahydro-2-pentalenyl]ethoxy)acetate | C29H54O5Si | 详情 | 详情 | |
(XXIVb) | 14841 | methyl 2-(2-[(2R,3aS,4S,5R,6aS)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-[(E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]octahydro-2-pentalenyl]ethoxy)acetate | C29H54O5Si | 详情 | 详情 | |
(XXIIIb) | 14841 | methyl 2-(2-[(2R,3aS,4S,5R,6aS)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-[(E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]octahydro-2-pentalenyl]ethoxy)acetate | C29H54O5Si | 详情 | 详情 | |
(XXIVa) | 14842 | methyl 2-[2-((2S,3aR,4R,5S,6aR)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-[(2S)-3-[(1R,3S)-1-hydroxy-3-methylheptyl]oxiranyl]octahydro-2-pentalenyl)ethoxy]acetate | C29H54O6Si | 详情 | 详情 |