• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】14759

【品名】[5-hydroxy-4-[([2-[((E)-[3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methylidene)amino]ethyl]imino)methyl]-6-methyl-3-pyridinyl]methyl dihydrogen phosphate

【CA登记号】

【 分 子 式 】C18H24N4O10P2

【 分 子 量 】518.357044

【元素组成】C 41.71% H 4.67% N 10.81% O 30.87% P 11.95%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The condensation of pyridoxal 5-phosphate (I) with ethylenediamine (II) in methanol by means of NaOH gives the corresponding diimine (III), which is reduced with hydrogen over Pt/C in methanol/water yielding the expected diamine (IV). The reaction of (IV) with bromoacetic acid (V) by means of NaOH in methanol/water affords the N,N'-diacetic acid derivative (VI), which is finally treated with MnCl2 in water containing NaOH.

1 Rocklage, S.M.; Cacheris, W.P.; Quay, S.C.; Hahn, F.E.; Raymond, K.N.; Manganese(II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate). Synthesis and characterization of a paramagnetic chelate for magnetic resonance imaging enhancement. Inorg Chem 1989, 28, 477-85.
2 Graul, A.; Leeson, P.; Castaner, J.; Mangafodipir Trisodium. Drugs Fut 1997, 22, 9, 974.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 14753 Pyridoxal 5'-phosphate; (4-formyl-5-hydroxy-6-methyl-3-pyridinyl)methyl dihydrogen phosphate 54-47-7 C8H10NO6P 详情 详情
(II) 14754 ethylenediamine;1,2-Diaminoethane;ethane-1,2-diamine;1,2-Ethanediamine 107-15-3 C2H8N2 详情 详情
(III) 14759 [5-hydroxy-4-[([2-[((E)-[3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methylidene)amino]ethyl]imino)methyl]-6-methyl-3-pyridinyl]methyl dihydrogen phosphate C18H24N4O10P2 详情 详情
(IV) 14756 [5-hydroxy-4-[([2-[([3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methyl)amino]ethyl]amino)methyl]-6-methyl-3-pyridinyl]methyl dihydrogen phosphate C18H28N4O10P2 详情 详情
(V) 23660 2-Bromoacetic acid 79-08-3 C2H3BrO2 详情 详情
(VI) 14758 2-[[2-[(carboxymethyl)([3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methyl)amino]ethyl]([3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methyl)amino]acetic acid C22H32N4O14P2 详情 详情
Extended Information