【结 构 式】 |
【分子编号】14644 【品名】(2R)-2-amino-3-[(3-hydroxypropyl)sulfanyl]propionic acid 【CA登记号】 |
【 分 子 式 】C6H13NO3S 【 分 子 量 】179.24016 【元素组成】C 40.21% H 7.31% N 7.81% O 26.78% S 17.89% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)Fudosteine has been obtained by two similar ways: 1) By condensation of L-cysteine (I) with 3-bromopropyl alcohol (II) by means of NaOH in water at room temperature. 2) By condensation of L-cysteine (I) with allyl alcohol (III) by means of potassium persulfate in water.
【1】 Castaner, J.; Leeson, P.; Wroblewski, T.; Fudosteine. Drugs Fut 1998, 23, 4, 374. |
【2】 Barnsley, E.A.; The formation of 2-hydroxypropylmercapturic acid from 1-halogenopropanes in the rat. Biochem J 1996, 100, 362-72. |
【3】 Itoh, Y.; Mizuno, H.; Kiyohara, C.; Sato, S.; Katori, T. (SSP Co., Ltd.); Expectorant comprising hydroxy-alkylcysteine deriv. EP 0346882; EP 0346883; JP 1990003674; US 4906665 . |
【4】 Ito, Y.; Kuriyama, T.; Ogawa, M.; Sato, S.; Kuraishi, T. (SSP Co., Ltd.); Preparation method of S-hydroxypropyl-L-cysteine. JP 1996119932 . |
Extended Information