(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl N-[3-(pentyloxy)phenyl]carbamate -Drug Synthesis Database

【结构式】

【分子编号】14638

【品名】(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl N-[3-(pentyloxy)phenyl]carbamate

【CA登记号】

【分子式】C₂₂H₃₄N₂O₃

【分子量】374.52364

【元素组成】C 70.55% H 9.15% N 7.48% O 12.82%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Trapencaine is prepared from 3-(n-pentyloxy)phenylisocyanate and (+)-trans-2-(1-pyrrolidinyl)cyclohexanol in dry benzene or some other inert solvent. Stereochemically pure isomer is obtained by treatment of the pure base with hydrochloric acid, yielding the corresponding salt.

参考文献中间体

合成目标

【1】 Benes, L.; Trapencaine Hydrochloride. Drugs Fut 1991, 16, 7, 627.
【2】 Benes, L.; Borovansky, A.; Kopácová, L.; Alkoxycarbanilic acid esters with high local anaesthetic activity. Arzneim-Forsch Drug Res 1969, 19, 1902-3.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	14636	3-(pentyloxy)phenyl isocyanate; 1-isocyanato-3-(pentyloxy)benzene	C₁₂H₁₅NO₂	详情	详情
(II)	14637	(1R,2R)-2-(1-pyrrolidinyl)cyclohexanol	C₁₀H₁₉NO	详情	详情
(III)	14638	(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl N-[3-(pentyloxy)phenyl]carbamate	C₂₂H₃₄N₂O₃	详情	详情

Extended Information