(3-Bromophenyl)(trimethyl)silane; (3-Bromophenyl)trimethylsilane -Drug Synthesis Database

【结构式】

【分子编号】14587

【品名】(3-Bromophenyl)(trimethyl)silane; (3-Bromophenyl)trimethylsilane

【CA登记号】17878-47-6

【分子式】C₉H₁₃BrSi

【分子量】229.19172

【元素组成】C 47.17% H 5.72% Br 34.86% Si 12.25%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of 1,3-dibromobenzene (I) with trimethylsilyl chloride (II) by means of Mg in ethyl ether gives 3-(trimethylsilyl)bromobenzene (III), which is then condensed with ethyl trifluoroacetate (IV) by means of butyllithium in ethyl ether - hexane.

参考文献中间体

合成目标

【1】 Schirlin, D.; Collard, J.-N.; Hornsperger, J.-M. (Merrell Pharmaceuticals, Inc.); Novel acetylcholinesterase inhibitors. EP 0403713; EP 0409676; JP 1991038591; US 5693668 .
【2】 Prous, J.; Graul, A.; Castaner, J.; Subreum. Drugs Fut 1994, 19, 9, 845.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	13370	1,3-Dibromobenzene	108-36-1	C₆H₄Br₂	详情	详情
(III)	14587	(3-Bromophenyl)(trimethyl)silane; (3-Bromophenyl)trimethylsilane	17878-47-6	C₉H₁₃BrSi	详情	详情
(IV)	14588	Ethyl 2,2,2-trifluoroacetate; Trifluoroethyl acetate	383-63-1	C₄H₅F₃O₂	详情	详情

Extended Information