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【结 构 式】 
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【分子编号】14551 【品名】3-(bromomethyl)-7-chloro-1-benzothiophene 【CA登记号】17512-61-7 |
【 分 子 式 】C9H6BrClS 【 分 子 量 】261.56934 【元素组成】C 41.33% H 2.31% Br 30.55% Cl 13.55% S 12.26% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(II)Sertaconazole nitrate has been synthesized by condensation of 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol (I) with 3-(bromomethyl)-7-chlorobenzo[b]thiophene (II) by means of NaH in HMPT, followed by salification with HNO3.
| 【1】 Moreno-Mañas, M.; Raga, M.M.; Palacín, C.; Ortiz, J.A.; Cuberes, M.R.; Castelló, J.M.; Synthesis and antimycotic activity of (benzo[b]thienyl)methyl ethers of 1 -(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol and of (Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone oxime. Arzneim-Forsch Drug Res 1992, 42, 5a, 691. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14550 | 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-1-ethanol; alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol; 1-(2',4'-Dichlorophenyl)-2-(1-imidazolyl)ethanol | 24155-42-8 | C11H10Cl2N2O | 详情 | 详情 |
| (II) | 14551 | 3-(bromomethyl)-7-chloro-1-benzothiophene | 17512-61-7 | C9H6BrClS | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(III)
| 【1】 Foguet R, Ramentol J. Guglietta A. et al. 2003. Preparation of R-(一）-1-[2-(7-chlorobenzo.[b] thiophen-3-yl-methoxy)-2-(2,4-dichlorophenyl)-ethyl}lH-imidazole,i,e. R-(-)-sertaconuole, for the treatment of fungal infections．W0 2003068770(本专利属于Ferrer Intemacional S A，Spain) |
Extended Information