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【结 构 式】 
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【分子编号】14476 【品名】(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid 【CA登记号】 |
【 分 子 式 】C21H26F2O5 【 分 子 量 】396.4312464 【元素组成】C 63.63% H 6.61% F 9.58% O 20.18% |
合成路线1
该中间体在本合成路线中的序号：(II)The oxidation of flumethasone (I) with oxygen and K2CO3 in methanol gives 6alpha,9alpha-difluoro-11beta,17alpha-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carboxylic acid (II), which is partially acylated with propionic anhydride in pyridine to afford the corresponding 17alpha-propionyloxy derivative (III) . The reaction of (III) with dimethylthiocarbamoyl chloride and triethylamine in dichloromethane gives the corresponding carbothioic acid (IV), which is esterified with bromochloromethane and sodium bicarbonate in dimethylacetamide yielding the chloromethyl carbothioate ester (V). Finally, this compound is treated with AgF in acetonitrile.
| 【1】 Edwards, J.A. (Syntex (USA), Inc.); 17beta-Thiocarboxylic acid esters of 6alpha,6beta-difluoro-3-oxoandrost-4-enes. US 4187301 . |
| 【2】 Phillips, G.H.; Bain, B.M.; Williamson, C.; Steeples, I.P.; Laing, S.B. (Glaxo Wellcome plc); Androstane 17beta-carbothioates. GB 2088877; NL 8100707; US 4335121 . |
| 【3】 Castaner, J.; Prous, J.; Fluticasone Propionate. Drugs Fut 1991, 16, 5, 424. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14475 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one | 2557-49-5 | C22H28F2O5 | 详情 | 详情 |
| (II) | 14476 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid | C21H26F2O5 | 详情 | 详情 | |
| (III) | 14477 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid | C24H30F2O6 | 详情 | 详情 | |
| (IV) | 14478 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid | C24H30F2O5S | 详情 | 详情 | |
| (V) | 14479 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-17-[[(chloromethyl)sulfanyl]carbonyl]-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate | C25H31ClF2O5S | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(I)New methods for the synthesis of fluticasone propionate have been reported: 1) The reaction of 6alpha,9alpha-difluoro-11beta,17alpha-dihydroxy-16alpha-methyl-3-oxo and rosta-1,4-diene-17beta-carboxylic acid (I) with carbonyldiimidazole (CDI) and H2S in DMF gives the corresponding carbothioic acid (II), which is selectively acylated with propionyl chloride and triethylamine in CH2Cl2, yielding the 17alpha-propionyloxy derivative (III). The reaction of (III) with CH2BrCl and NaHCO3 in DMA affords the S-chloromethyl ester (IV), which by reaction with NaI in refluxing acetone is converted to the S-iodomethyl ester (V). Finally, this compound is treated with AgF in acetonitrile. 2) By esterification of thioacid (II) with bromofluoromethane or fluoroiodomethane by means of K2CO3 in DMF.
| 【1】 Phillips, G.H.; Bain, B.M.; Williamson, C.; Steeples, I.P.; Laing, S.B. (Glaxo Wellcome plc); Androstane 17beta-carbothioates. GB 2088877; NL 8100707; US 4335121 . |
| 【2】 Phillips, G.H.; Bailey, E.J.; Bain, B.M.; et al.; Synthesis and structure-activity relationships in a series of antiinflammatory corticosteroid analogues, halomethyl androstane-17beta-carbothioates and -17beta-carboselenoates. J Med Chem 1994, 37, 22, 3717. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14476 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid | C21H26F2O5 | 详情 | 详情 | |
| (II) | 14481 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid | C21H26F2O4S | 详情 | 详情 | |
| (III) | 14478 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid | C24H30F2O5S | 详情 | 详情 | |
| (IV) | 14479 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-17-[[(chloromethyl)sulfanyl]carbonyl]-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate | C25H31ClF2O5S | 详情 | 详情 | |
| (V) | 14484 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-17-[[(iodomethyl)sulfanyl]carbonyl]-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate | C25H31F2IO5S | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(II)The oxidation of flumethasone (I) with Pd(OAc)2, PPh3 and IO4H in DMA gives the 17-beta-carboxylic acid (II), which is selectively monoacylated with propionyl chloride (III) and Et2NH in acetone, yielding the 17-alpha-propionyloxy derivative (IV). The reaction of (IV) with N,N-dimethylthiocarbamoyl chloride (V), TEA and NaI in 2-butanone affords the thioanhydride (VI), which is finally treated with chlorofluoromethane and SHNa in DMA to provide the desired fluoromethyl thioester.
| 【1】 Cooper, A.J.; Chamberlin, S.A.; Hufnagel, J.J.; Barkalow, J.; Hossain, A.; Langridge, D.C. (Abbott Laboratories Inc.); Method for the preparation of fluticasone and related 17betaETA-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods. WO 0162722 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14475 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one | 2557-49-5 | C22H28F2O5 | 详情 | 详情 |
| (II) | 14476 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid | C21H26F2O5 | 详情 | 详情 | |
| (III) | 15967 | propanoyl chloride; propionyl chloride | 79-03-8 | C3H5ClO | 详情 | 详情 |
| (IV) | 14477 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid | C24H30F2O6 | 详情 | 详情 | |
| (V) | 54928 | Dimethylthiocarbamoyl chloride; N,N-Dimethylthiocarbamoyl chloride | 16420-13-6 | C3H6ClNS | 详情 | 详情 |
| (VI) | 54929 | C27H35F2NO6S | 详情 | 详情 | ||
| (VII) | 54930 | Chlorofluoromethane; Monochloromonofluoromethane | 593-70-4 | CH2ClF | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(I)The starting 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid (I) is converted to the analogous carbothioic acid (II) via activation with carbonyl diimidazole, followed by reaction with hydrogen sulfide gas (1). The α-hydroxyl group of (II) is then selectively acylated with 2-furoyl chloride (III) to give the 17-furoate ester (IV) (2, 3). Finally, condensation of thioacid (IV) with bromofluoromethane under basic conditions provides the target fluoromethyl thioester (2-4).
| 【1】 Phillipps, G.H., Bain, B.M., Williamson, C., Steeples, I.P., Laing, S.B. (Glaxo Group, Ltd.). Androstane 17β-carbothioates. GB 2088877. |
| 【2】 Biggadike, K., Jones, P., Payne, J.J. (Glaxo Group, Ltd.). 17beta-Carbothioate 17alpha-arylcarbonyloxyoxy androstane derivative as anti-inflammatory agents. EP 1305330, JP 2004505990, US 6537983, US 2003045512, WO 0212266. |
| 【3】 Biggadike, K., Coote, S.J., Noga, B., Van Oort, M.M. (Glaxo Group, Ltd.). Amorphous fluticasone 2-furoate, pharmaceutical compositions thereof and its conversion to the crystalline unsolvated form. EP 1480996, JP 2005522442, US 2005152845, WO 03066655. |
| 【4】 Partridge, J.J., Walker, D.S. (SmithKline Beecham Corp.). A method for preparing fluticasone derivatives. WO 03013427. 5. Prous Science Disease Briefings: Allergic Rhinitis (online publication). Updated 2007. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14476 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid | C21H26F2O5 | 详情 | 详情 | |
| (II) | 14481 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid | C21H26F2O4S | 详情 | 详情 | |
| (III) | 26093 | 2-Furoyl chloride | 527-69-5 | C5H3ClO2 | 详情 | 详情 |
| (IV) | 65207 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-17-furoyloxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid | C26H26F2O6S | 详情 | 详情 |