4-(2-[2-[(2,2-Dimethylpropanoyl)amino]-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl]ethynyl)benzoic acid -Drug Synthesis Database

【结构式】

【分子编号】14289

【品名】4-(2-[2-[(2,2-Dimethylpropanoyl)amino]-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl]ethynyl)benzoic acid

【CA登记号】

【分子式】C₂₁H₁₈N₄O₄

【分子量】390.39848

【元素组成】C 64.61% H 4.65% N 14.35% O 16.39%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIII)

Racemic lometrexol has been prepared.

参考文献中间体

合成目标

【1】 Harrington, P.M.; Shih, C.; Grindey, G.B.; Gossett, L.S.; Moran, R.G.; Taylor, S.C.; Synthesis and structure-activity relationship studies of 5,10-dideazatetrahydrofolic acid (DDATHF). Chemistry and Biology of Pteridines (1989): Pteridines and Folic Acid Derivatives. H.-C. Curtius, S. Ghisla and N. Blau (Eds.). de Gruyter, New York 1990, 1035.
【2】 Taylor, E.C.; Wong, G.S.K.; Convergent and efficient palladium-effected synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF). J Org Chem 1989, 54, 15, 3618.
【3】 Castaner, J.; Prous, J.; Lometrexol. Drugs Fut 1993, 18, 2, 121.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
	51602	1-Propyne	C₃H₄	详情	详情
(I)	14277	2,6-Diamino-4(3H)-pyrimidinone	C₄H₆N₄O	详情	详情
(II)	14278	2-Bromomalonaldehyde	C₃H₃BrO₂	详情	详情
(III)	14279	2-Amino-6-bromopyrido[2,3-d]pyrimidin-4(3H)-one	C₇H₅BrN₄O	详情	详情
(IV)	14280	N-(6-Bromo-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide	C₁₂H₁₃BrN₄O₂	详情	详情
(V)	14281	2,2-Dimethyl-N-[4-oxo-6-[2-(trimethylsilyl)ethynyl]-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]propanamide	C₁₇H₂₂N₄O₂Si	详情	详情
(VI)	14282	N-(6-Ethynyl-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide	C₁₄H₁₄N₄O₂	详情	详情
(VII)	14283	diethyl (2S)-2-[(4-iodobenzoyl)amino]pentanedioate	C₁₆H₂₀INO₅	详情	详情
(VIII)	14284	diethyl (2S)-2-[[4-(2-[2-[(2,2-dimethylpropanoyl)amino]-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl]ethynyl)benzoyl]amino]pentanedioate	C₃₀H₃₃N₅O₇	详情	详情
(IX)	14285	tert-butyl 4-ethynylbenzoate	C₁₃H₁₄O₂	详情	详情
(X)	14286	tert-butyl 4-bromobenzoate	C₁₁H₁₃BrO₂	详情	详情
(XI)	14287	diethyl (2S)-2-[(4-ethynylbenzoyl)amino]pentanedioate	C₁₈H₂₁NO₅	详情	详情
(XII)	14288	tert-butyl 4-(2-[2-[(2,2-dimethylpropanoyl)amino]-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl]ethynyl)benzoate	C₂₅H₂₆N₄O₄	详情	详情
(XIII)	14289	4-(2-[2-[(2,2-Dimethylpropanoyl)amino]-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl]ethynyl)benzoic acid	C₂₁H₁₈N₄O₄	详情	详情
(XIV)	11013	diethyl (2S)-2-aminopentanedioate	C₉H₁₇NO₄	详情	详情
(XV)	14291	diethyl (2S)-2-[[4-(2-[2-[(2,2-dimethylpropanoyl)amino]-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl)benzoyl]amino]pentanedioate	C₃₀H₄₁N₅O₇	详情	详情

Extended Information