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【结 构 式】

【分子编号】14272

【品名】methyl 4-[(E)-2-(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)ethenyl]benzoate

【CA登记号】

【 分 子 式 】C17H15N5O2

【 分 子 量 】321.3386

【元素组成】C 63.54% H 4.71% N 21.79% O 9.96%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Racemic lometrexol has been prepared.

1 Okazaki, S.; Asao, T.; Wakida, M.; Ishida, K.; Washinosu, M.; Utsugi, T.; Yamada, Y. (Taiho Pharmaceutical Co., Ltd.); Novel fused indan deriv. and pharmaceutically acceptable salt. EP 0713870; US 5710162; US 5733918; WO 9532187 .
2 Castaner, J.; Prous, J.; Lometrexol. Drugs Fut 1993, 18, 2, 121.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(VI*) 11013 diethyl (2S)-2-aminopentanedioate C9H17NO4 详情 详情
(I) 14269 2,4-Diaminopyrido[2,3-d]pyrimidine-6-carbonitrile C8H6N6 详情 详情
(II) 14270 2,4-Diaminopyrido[2,3-d]pyrimidine-6-carbaldehyde C8H7N5O 详情 详情
(III) 14271 [4-(Methoxycarbonyl)benzyl](diphenyl)phosphonium C21H20O2P 详情 详情
(IV) 14272 methyl 4-[(E)-2-(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)ethenyl]benzoate C17H15N5O2 详情 详情
(V) 14273 4-[(E)-2-(2-Amino-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl)ethenyl]benzoic acid C16H12N4O3 详情 详情
(VII) 14275 diethyl (2S)-2-([4-[(E)-2-(2-amino-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl)ethenyl]benzoyl]amino)pentanedioate C25H27N5O6 详情 详情
(VIII) 14276 diethyl (2S)-2-([4-[2-(2-amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoyl]amino)pentanedioate C25H33N5O6 详情 详情
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