(2R)-2-(Dimethylamino)-2-phenyl-1-butanol -Drug Synthesis Database

【结构式】

【分子编号】14071

【品名】(2R)-2-(Dimethylamino)-2-phenyl-1-butanol

【CA登记号】

【分子式】C₁₂H₁₉NO

【分子量】193.289

【元素组成】C 74.57% H 9.91% N 7.25% O 8.28%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(+)-(I)

Fedotozine (-)-tartrate can be prepared by two different methods: a) Conventional resolution in ethanol of racemic (±)-N,N-dimethyl-1-[(3,4,5-trimethoxybenzyl)oxymethyl]-1-phenyl-n-propylamine with (-)-tartaric acid. b) Condensation of (+)-2-dimethylamino-2-phenyl-n-butanol (I) with 3,4,5-trimethoxybenzyl chloride (II) gives (+)-N,N-dimethyl-1-[(3,4,5-trimethoxybenzyl)oxymethyl]-1-phenyl-n-propylamine, which is salified with (-)-tartaric acid in ethanol to give fedotozine (-)-tartrate.

参考文献中间体

合成目标

【1】 Homerin, M.; Geneve, J.; Karaus, M.; Korber, J.; Fedotozine Tartrate. Drugs Fut 1992, 17, 2, 101.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(+)-(I)	14071	(2R)-2-(Dimethylamino)-2-phenyl-1-butanol		C₁₂H₁₉NO	详情	详情
(II)	14072	3,4,5-Trimethoxybenzyl chloride; 5-(Chloromethyl)-1,2,3-trimethoxybenzene; 4-(Chloromethyl)-2,6-dimethoxyphenyl methyl ether	3840-30-0	C₁₀H₁₃ClO₃	详情	详情

Extended Information