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【结 构 式】 
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【分子编号】14017 【品名】Dimethyl hydrogen phosphite 【CA登记号】96-36-6 |
【 分 子 式 】C2H7O3P 【 分 子 量 】110.049542 【元素组成】C 21.83% H 6.41% O 43.62% P 28.15% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Metrifonate is easily synthesized in a one-step spontaneous exothermic condensation of equimolar amounts of chloral hydrate with dimethylhydrogenphosphite, which in turn is accessible by reacting PCl3 with methanol. Contrary to similar reactions described earlier (1950-1952) in two Soviet papers and a U.S. process patent, no catalyst is needed if the aldehyde compound is chloral. Therefore, metrifonate can be readily crystallized directly from the reaction mixture.
| 【1】 Mucke, H.A.M.; Metrifonate. Drugs Fut 1998, 23, 5, 491. |
| 【2】 Giang, P.A.; Barthel, W.F.; Hall, S.A.; Dialkylalpha-hydroxyphosphonates derived from chloral. J Am Chem Soc 1954, 76, 4186-7. |
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