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【结 构 式】 
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【分子编号】13623 【品名】Theophylline sodium salt; 1,3-Dimethylxanthine sodium salt 【CA登记号】 |
【 分 子 式 】C7H7N4NaO2 【 分 子 量 】202.148108 【元素组成】C 41.59% H 3.49% N 27.72% Na 11.37% O 15.83% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)By reaction of theophylline sodium salt with isobutyl halogenide in N,N-dimethylformamide at 80 C.
| 【1】 Fedi, M.; Bonacchi, G. (Malesci Ist. Farmacobiol. SpA); Xanthine derivs., pharmaceutical compsns. containing same and their therapeutic use. US 4544556 . |
| 【2】 Bonacchi, G.; Manzini, S.; Dapporto, P.; Paoli, P.; Crystal structure of a new antibronchospastic drug: 1,3-dimethyl-7-isobutylxanthine (TE 06). In: Three-Dimensional Molecular Structure and Drug Action - 15th Course of International School of Crystallography (June 1-11, Erice) 1989, Poster No. 8. |
| 【3】 Manzini, S.; Fedi, M.; Bonacchi, G.; Agostini, O.; ISBUFYLLINE. Drugs Fut 1990, 15, 3, 228. |
Extended Information