Carbamic acid,[(1R)-1-(2R)-oxiranyl-2-phenylethyl]-, 1,1-dimethylethyl ester, rel- ;Carbamicacid, (1-oxiranyl-2-phenylethyl)-, 1,1-dimethylethyl ester, (R*,R*)-(à)-;Carbamic acid,(1-oxiranyl-2-phenylethyl)-, 1,1-dimethylethyl ester, (R*,R*)- -Drug Synthesis Database

【结构式】

【分子编号】66218

【品名】Carbamic acid,[(1R)-1-(2R)-oxiranyl-2-phenylethyl]-, 1,1-dimethylethyl ester, rel- ;Carbamicacid, (1-oxiranyl-2-phenylethyl)-, 1,1-dimethylethyl ester, (R*,R*)-(à)-;Carbamic acid,(1-oxiranyl-2-phenylethyl)-, 1,1-dimethylethyl ester, (R*,R*)-

【CA登记号】98818-34-9

【分子式】C₁₅H₂₁NO₃

【分子量】263.33668

【元素组成】C 68.42% H 8.04% N 5.32% O 18.23%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

参考文献中间体

合成目标

【1】 Goyvaerts NMF, Wigerinck PTBP, et al.2005. Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] funur-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl](isobutyl) amino}l-benzyl-2-hydroxy-propylcarbamate from l-oxirayl-2-phenylethylcarbamates. W0 2005063770
【2】 Surleraux DLNG, Tahri A.et aL 2005. Discovery and selection ofTMC114,a next genention HIV-1 protease inhibitor.JMed Chem, 48. 1813~1822

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
（V）	44938	tert-butyl (1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propylcarbamate		C₂₅H₃₅N₃O₇S	详情	详情
(I)	32815	(3R,3aS,6aR)hexahydrofuro[2,3-b]furan-3-ol		C₆H₁₀O₃	详情	详情
(II)	32812	1-([[(3R,3aS,6aR)hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl]oxy)-2,5-pyrrolidinedione		C₁₁H₁₃NO₇	详情	详情
(III)	66218	Carbamic acid,[(1R)-1-(2R)-oxiranyl-2-phenylethyl]-, 1,1-dimethylethyl ester, rel- ;Carbamicacid, (1-oxiranyl-2-phenylethyl)-, 1,1-dimethylethyl ester, (R,R)-(à)-;Carbamic acid,(1-oxiranyl-2-phenylethyl)-, 1,1-dimethylethyl ester, (R,R)-	98818-34-9	C₁₅H₂₁NO₃	详情	详情
(IV)	44417	tert-butyl (1S,2R)-1-benzyl-2-hydroxy-3-(isobutylamino)propylcarbamate	160232-08-6	C₁₉H₃₂N₂O₃	详情	详情
(VI)	45533	4-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-isobutylbenzenesulfonamide		C₂₀H₂₉N₃O₃S	详情	详情

Extended Information