(6aR,7S,8aS,8bS,11aR,12bS)-7-hydroxy-8b-isobutyryl-6a,8a,10,10-tetramethyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one -Drug Synthesis Database

【结构式】

【分子编号】66191

【品名】(6aR,7S,8aS,8bS,11aR,12bS)-7-hydroxy-8b-isobutyryl-6a,8a,10,10-tetramethyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one

【CA登记号】　

【分子式】C₂₆H₃₆O₅

【分子量】428.56884

【元素组成】C 72.87% H 8.47% O 18.67%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

参考文献中间体

合成目标

【1】 Pierluigi R,MacDonald P.2007.Improved process for the preparation of ciclesonide. W0 2007056181

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	22334	1-methylpropionic anhydride	97-72-3	C₈H₁₄O₃	详情	详情
(II)	66190	(6aS,7R,8aR,8bR,11aS,12bR)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one		C₂₄H₃₂O₆	详情	详情
(III)	66191	(6aR,7S,8aS,8bS,11aR,12bS)-7-hydroxy-8b-isobutyryl-6a,8a,10,10-tetramethyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one		C₂₆H₃₆O₅	详情	详情
(IV)	38916	2-[(4aR,5S,6aS,8S,9aR)-8-cyclohexyl-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6-yl]-2-oxoethyl 2-methylpropanoate		C₃₂H₄₄O₇	详情	详情
(IV)	33694	cyclohexanecarbaldehyde	2043-61-0	C₇H₁₂O	详情	详情

Extended Information