|
【结 构 式】 
|
【分子编号】13395 【品名】1-Cyclopropyl-6,8-difluoro-7-[2-[(formylamino)methyl]-4-morpholinyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid 【CA登记号】 |
【 分 子 式 】C19H19F2N3O5 【 分 子 量 】407.3738864 【元素组成】C 56.02% H 4.7% F 9.33% N 10.31% O 19.64% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The condensation of 1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (I) with 2-(formylamino-methyl)- morpholine (II) by means of 1,8-diazabicyclo[5.4.0]-7-undecene (DABU) in refluxing acetonitrile gives the formamido derivative (III), which is then hydrolyzed with concentrated HCl in refluxing methanol.
| 【1】 Araki, K.; Kuroda, T.; Uemori, S.; Moriguchi, A.; Ikeda, Y. (Welfide Corporation); Quinolonecarboxylic acid cpds. and pharmaceutical use thereof. EP 0311948; US 4889857 . |
| 【2】 Castaner, J.; Prous, J.; Y-26611. Drugs Fut 1992, 17, 2, 114. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13393 | 1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C13H8F3NO3 | 详情 | 详情 | |
| (II) | 13394 | 2-Morpholinylmethylformamide | C6H12N2O2 | 详情 | 详情 | |
| (III) | 13395 | 1-Cyclopropyl-6,8-difluoro-7-[2-[(formylamino)methyl]-4-morpholinyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C19H19F2N3O5 | 详情 | 详情 |
Extended Information