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【结 构 式】

【分子编号】13395

【品名】1-Cyclopropyl-6,8-difluoro-7-[2-[(formylamino)methyl]-4-morpholinyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

【CA登记号】

【 分 子 式 】C19H19F2N3O5

【 分 子 量 】407.3738864

【元素组成】C 56.02% H 4.7% F 9.33% N 10.31% O 19.64%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The condensation of 1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (I) with 2-(formylamino-methyl)- morpholine (II) by means of 1,8-diazabicyclo[5.4.0]-7-undecene (DABU) in refluxing acetonitrile gives the formamido derivative (III), which is then hydrolyzed with concentrated HCl in refluxing methanol.

1 Araki, K.; Kuroda, T.; Uemori, S.; Moriguchi, A.; Ikeda, Y. (Welfide Corporation); Quinolonecarboxylic acid cpds. and pharmaceutical use thereof. EP 0311948; US 4889857 .
2 Castaner, J.; Prous, J.; Y-26611. Drugs Fut 1992, 17, 2, 114.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 13393 1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid C13H8F3NO3 详情 详情
(II) 13394 2-Morpholinylmethylformamide C6H12N2O2 详情 详情
(III) 13395 1-Cyclopropyl-6,8-difluoro-7-[2-[(formylamino)methyl]-4-morpholinyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid C19H19F2N3O5 详情 详情
Extended Information