N-(2-[[(1S)-1-(Chloromethyl)-5-hydroxy-8-methyl-1,6-dihydropyrrolo[3,2-e]indol-3(2H)-yl]carbonyl]-1H-indol-5-yl)-6-(diethylamino)-1-benzofuran-2-carboxamide -Drug Synthesis Database

【结构式】

【分子编号】13352

【品名】N-(2-[[(1S)-1-(Chloromethyl)-5-hydroxy-8-methyl-1,6-dihydropyrrolo[3,2-e]indol-3(2H)-yl]carbonyl]-1H-indol-5-yl)-6-(diethylamino)-1-benzofuran-2-carboxamide

【CA登记号】

【分子式】C₃₄H₃₂ClN₅O₄

【分子量】610.11208

【元素组成】C 66.93% H 5.29% Cl 5.81% N 11.48% O 10.49%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

By condensation of (S)-N-[2-[1-(chloromethyl)-5-hydroxy-8-methyl-1,2,3,6-tetrahydrobenzo [1,2-b:4,3-b']dipyrrol-3-ylcarbonyl]-1H-indol-5-yl]-6-(diethylamino) benzofuran-2-carboxamide (I) with phenyl isocyanate (II) by means of triethylamine in THF.

参考文献中间体

合成目标

【1】 Mealy, N.; Castaner, J.; Carzelesin. Drugs Fut 1996, 21, 3, 245.
【2】 Kelly, R.C.; Martin, D.G.; Aristoff, P.A. (Pharmacia Corp.); Novel CC-1065 analogs. AU 8812290; EP 0340243; WO 8804659 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	13352	N-(2-[[(1S)-1-(Chloromethyl)-5-hydroxy-8-methyl-1,6-dihydropyrrolo[3,2-e]indol-3(2H)-yl]carbonyl]-1H-indol-5-yl)-6-(diethylamino)-1-benzofuran-2-carboxamide		C₃₄H₃₂ClN₅O₄	详情	详情
(II)	11289	1-Isocyanatobenzene; phenyl isocyanate; Phenylisocyanate	103-71-9	C₇H₅NO	详情	详情

Extended Information